Jennifer Bryant1, Mark Hanson1, Charles Peebles1, Lucy Davies1, Hazel Inskip1, Sian Robinson1, Philip C Calder1, Cyrus Cooper1, Keith M Godfrey2. 1. From the NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust (UHSFT) (J.B., M.H., S.R., P.C.C., C.C., K.M.G.), MRC Lifecourse Epidemiology Unit (J.B., L.D., H.I., S.R., C.C., K.M.G.), and Human Development and Health Academic Unit, Faculty of Medicine (M.H., H.I., S.R., P.C.C., C.C., K.M.G.), University of Southampton, Southampton, United Kingdom; and Department of Radiology (J.B., C.P.), UHSFT, Southampton, United Kingdom. 2. From the NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust (UHSFT) (J.B., M.H., S.R., P.C.C., C.C., K.M.G.), MRC Lifecourse Epidemiology Unit (J.B., L.D., H.I., S.R., C.C., K.M.G.), and Human Development and Health Academic Unit, Faculty of Medicine (M.H., H.I., S.R., P.C.C., C.C., K.M.G.), University of Southampton, Southampton, United Kingdom; and Department of Radiology (J.B., C.P.), UHSFT, Southampton, United Kingdom. kmg@mrc.soton.ac.uk.
Abstract
RATIONALE: Higher pulse wave velocity (PWV) reflects increased arterial stiffness and is an established cardiovascular risk marker associated with lower long-chain n-3 polyunsaturated fatty acid intake in adults. Experimentally, maternal fatty acid intake in pregnancy has lasting effects on offspring arterial stiffness. OBJECTIVE: To examine the association between maternal consumption of oily fish, a source of long-chain n-3 polyunsaturated fatty acids, in pregnancy and child's aortic stiffness age 9 years. METHODS AND RESULTS: In a mother-offspring study (Southampton Women's Survey), the child's descending aorta PWV was measured at the age of 9 years using velocity-encoded phase-contrast MRI and related to maternal oily fish consumption assessed prospectively during pregnancy. Higher oily fish consumption in late pregnancy was associated with lower childhood aortic PWV (sex-adjusted β=-0.084 m/s per portion per week; 95% confidence interval, -0.137 to -0.031; P=0.002; n=226). Mother's educational attainment was independently associated with child's PWV. PWV was not associated with the child's current oily fish consumption. CONCLUSIONS: Level of maternal oily fish consumption in pregnancy may influence child's large artery development, with potential long-term consequences for later cardiovascular risk.
RATIONALE: Higher pulse wave velocity (PWV) reflects increased arterial stiffness and is an established cardiovascular risk marker associated with lower long-chain n-3 polyunsaturated fatty acid intake in adults. Experimentally, maternal fatty acid intake in pregnancy has lasting effects on offspring arterial stiffness. OBJECTIVE: To examine the association between maternal consumption of oily fish, a source of long-chain n-3 polyunsaturated fatty acids, in pregnancy and child's aortic stiffness age 9 years. METHODS AND RESULTS: In a mother-offspring study (Southampton Women's Survey), the child's descending aorta PWV was measured at the age of 9 years using velocity-encoded phase-contrast MRI and related to maternal oily fish consumption assessed prospectively during pregnancy. Higher oily fish consumption in late pregnancy was associated with lower childhood aortic PWV (sex-adjusted β=-0.084 m/s per portion per week; 95% confidence interval, -0.137 to -0.031; P=0.002; n=226). Mother's educational attainment was independently associated with child's PWV. PWV was not associated with the child's current oily fish consumption. CONCLUSIONS: Level of maternal oily fish consumption in pregnancy may influence child's large artery development, with potential long-term consequences for later cardiovascular risk.
Authors: Gary F Mitchell; Shih-Jen Hwang; Ramachandran S Vasan; Martin G Larson; Michael J Pencina; Naomi M Hamburg; Joseph A Vita; Daniel Levy; Emelia J Benjamin Journal: Circulation Date: 2010-01-18 Impact factor: 29.690
Authors: Heynric B Grotenhuis; Jos J M Westenberg; Paul Steendijk; Rob J van der Geest; Jaap Ottenkamp; Jeroen J Bax; J Wouter Jukema; Albert de Roos Journal: J Magn Reson Imaging Date: 2009-09 Impact factor: 4.813
Authors: Hazel M Inskip; Keith M Godfrey; Siân M Robinson; Catherine M Law; David J P Barker; Cyrus Cooper Journal: Int J Epidemiol Date: 2005-09-29 Impact factor: 7.196
Authors: Feiby L Nassan; Yu-Han Chiu; Jose C Vanegas; Audrey J Gaskins; Paige L Williams; Jennifer B Ford; Jill Attaman; Russ Hauser; Jorge E Chavarro Journal: Am J Clin Nutr Date: 2018-11-01 Impact factor: 7.045
Authors: Line Sletner; Sarah R Crozier; Hazel M Inskip; Keith M Godfrey; Pamela Mahon; Scott T Chiesa; Marietta Charakida; Cyrus Cooper; Mark Hanson Journal: J Hypertens Date: 2021-09-01 Impact factor: 4.776
Authors: Robert Murray; Negusse Kitaba; Elie Antoun; Philip Titcombe; Sheila Barton; Cyrus Cooper; Hazel M Inskip; Graham C Burdge; Pamela A Mahon; John Deanfield; Julian P Halcox; Elizabeth A Ellins; Jennifer Bryant; Charles Peebles; Karen Lillycrop; Keith M Godfrey; Mark A Hanson Journal: Hypertension Date: 2021-07-19 Impact factor: 10.190