Literature DB >> 25699154

Allosteric modulators: an emerging concept in drug discovery.

Ahmed F Abdel-Magid1.   

Abstract

Year:  2015        PMID： 25699154      PMCID： PMC4329591          DOI： 10.1021/ml5005365

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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  7 in total

Review 1.  Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors.

Authors:  Michael J Marino; P Jeffrey Conn
Journal:  Curr Opin Pharmacol       Date:  2005-12-20       Impact factor: 5.547

Review 2.  Allosteric modulation of dopamine receptors.

Authors:  John A Schetz
Journal:  Mini Rev Med Chem       Date:  2005-06       Impact factor: 3.862

3.  A new kind of drug target.

Authors:  Melinda Wenner
Journal:  Sci Am       Date:  2009-08       Impact factor: 2.142

Review 4.  mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents.

Authors:  Jean-Philippe Rocher; Béatrice Bonnet; Christelle Boléa; Robert Lütjens; Emmanuel Le Poul; Sonia Poli; Mark Epping-Jordan; Anne-Sophie Bessis; Bernard Ludwig; Vincent Mutel
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

Review 5.  Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach.

Authors:  Daniel Hoyer; Tamas Bartfai
Journal:  Chem Biodivers       Date:  2012-11       Impact factor: 2.408

Review 6.  Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates.

Authors:  Kyle C Schmitt; Richard B Rothman; Maarten E A Reith
Journal:  J Pharmacol Exp Ther       Date:  2013-04-08       Impact factor: 4.030

Review 7.  Use of allosteric targets in the discovery of safer drugs.

Authors:  Ashok Kumar Grover
Journal:  Med Princ Pract       Date:  2013-05-23       Impact factor: 1.927
  7 in total
  24 in total

Review 1.  Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs.

Authors:  Bharath Srinivasan; Sam Tonddast-Navaei; Ambrish Roy; Hongyi Zhou; Jeffrey Skolnick
Journal:  Med Res Rev       Date:  2018-09-07       Impact factor: 12.944

2.  Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis.

Authors:  Ghader Bashiri; Laura V Nigon; Ehab N M Jirgis; Ngoc Anh Thu Ho; Tamsyn Stanborough; Stephanie S Dawes; Edward N Baker; Esther M M Bulloch; Jodie M Johnston
Journal:  J Biol Chem       Date:  2020-02-06       Impact factor: 5.157

3.  Allosteric Impact of the Variable Insert Loop in Vaccinia H1-Related (VHR) Phosphatase.

Authors:  Victor A Beaumont; Krystle Reiss; Zexing Qu; Brandon Allen; Victor S Batista; J Patrick Loria
Journal:  Biochemistry       Date:  2020-05-06       Impact factor: 3.162

4.  Identification and characterization of fragment binding sites for allosteric ligand design using the site identification by ligand competitive saturation hotspots approach (SILCS-Hotspots).

Authors:  Alexander D MacKerell; Sunhwan Jo; Sirish Kaushik Lakkaraju; Christoffer Lind; Wenbo Yu
Journal:  Biochim Biophys Acta Gen Subj       Date:  2020-01-03       Impact factor: 3.770

Review 5.  High throughput and quantitative enzymology in the genomic era.

Authors:  D A Mokhtari; M J Appel; P M Fordyce; D Herschlag
Journal:  Curr Opin Struct Biol       Date:  2021-09-27       Impact factor: 6.809

Review 6.  Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles.

Authors:  Philip Coffino; Yifan Cheng
Journal:  Biomolecules       Date:  2022-05-30

7.  Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner.

Authors:  Ama Dedo Okyere; Jianliang Song; Viren Patwa; Rhonda L Carter; Nitya Enjamuri; Anna Maria Lucchese; Jessica Ibetti; Claudio de Lucia; Sarah M Schumacher; Walter J Koch; Joseph Y Cheung; Jeffrey L Benovic; Douglas G Tilley
Journal:  Cardiovasc Drugs Ther       Date:  2022-01-08       Impact factor: 3.947

Review 8.  Use of calcimimetics in children with normal kidney function.

Authors:  Judith Sebestyen VanSickle; Tarak Srivastava; Uri S Alon
Journal:  Pediatr Nephrol       Date:  2018-03-19       Impact factor: 3.714

9.  Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach.

Authors:  Bethany A Falls; Yan Zhang
Journal:  ACS Chem Neurosci       Date:  2018-08-13       Impact factor: 4.418

10.  Current Trends in GPCR Allostery.

Authors:  Khuraijam Dhanachandra Singh; Sadashiva S Karnik
Journal:  J Membr Biol       Date:  2021-01-20       Impact factor: 1.843
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