Abdirisak Ahmed Haji Omar1, Caj Haglund2, Susanna Virolainen3, Valtteri Häyry4, Timo Atula4, Risto Kontio5, Tuula Salo6, Timo Sorsa7, Jaana Hagström8. 1. Institute of Dentistry, University of Helsinki, Helsinki, Finland. Electronic address: Abdirisak.Ahmed@helsinki.fi. 2. Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland; Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland. 3. Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland. 4. Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland. 5. Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland. 6. Institute of Dentistry, University of Helsinki, Helsinki, Finland; Medical Research Center Oulu, University of Oulu, Oulu, Finland. 7. Institute of Dentistry, University of Helsinki, Helsinki, Finland; Division of Periodontology, Department of Dental Medicine, Karolinska Institute, Huddinge, Sweden. 8. Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland.
Abstract
OBJECTIVES: Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers. STUDY DESIGN: Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies. RESULTS: MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients. CONCLUSIONS: The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.
OBJECTIVES: Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers. STUDY DESIGN: Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies. RESULTS:MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients. CONCLUSIONS: The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.
Authors: Jonas Eichberger; Florian Weber; Gerrit Spanier; Michael Gerken; Stephan Schreml; Daniela Schulz; Mathias Fiedler; Nils Ludwig; Richard Josef Bauer; Torsten Eugen Reichert; Tobias Ettl Journal: Cancers (Basel) Date: 2022-08-22 Impact factor: 6.575