Literature DB >> 25691629

Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae.

Antonio Cannatelli1, Alfonso Santos-Lopez2, Tommaso Giani1, Bruno Gonzalez-Zorn2, Gian Maria Rossolini3.   

Abstract

The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae strains from clinical sources. In this work, we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and mgrB inactivation is not associated with a significant biological cost.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25691629      PMCID： PMC4394794          DOI： 10.1128/AAC.04998-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections.

Authors:  Matthew E Falagas; Sofia K Kasiakou
Journal:  Clin Infect Dis       Date:  2005-03-22       Impact factor: 9.079

2.  Colistin resistance in a clinical Acinetobacter baumannii strain appearing after colistin treatment: effect on virulence and bacterial fitness.

Authors:  Rafael López-Rojas; Michael J McConnell; Manuel Enrique Jiménez-Mejías; Juan Domínguez-Herrera; Felipe Fernández-Cuenca; Jerónimo Pachón
Journal:  Antimicrob Agents Chemother       Date:  2013-07-08       Impact factor: 5.191

Review 3.  Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies.

Authors:  Yun Cai; Dong Chai; Rui Wang; Beibei Liang; Nan Bai
Journal:  J Antimicrob Chemother       Date:  2012-03-22       Impact factor: 5.790

4.  Carbapenemase-producing Enterobacteriaceae in a tertiary hospital in Madrid, Spain: high percentage of colistin resistance among VIM-1-producing Klebsiella pneumoniae ST11 isolates.

Authors:  Irene Pena; Juan J Picazo; Carmen Rodríguez-Avial; Iciar Rodríguez-Avial
Journal:  Int J Antimicrob Agents       Date:  2014-02-22       Impact factor: 5.283

5.  Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43.

Authors:  Hsin-Yao Cheng; Yi-Fong Chen; Hwei-Ling Peng
Journal:  J Biomed Sci       Date:  2010-07-24       Impact factor: 8.410

Review 6.  Treatment of carbapenem-resistant Klebsiella pneumoniae: the state of the art.

Authors:  Nicola Petrosillo; Maddalena Giannella; Russell Lewis; Pierluigi Viale
Journal:  Expert Rev Anti Infect Ther       Date:  2013-02       Impact factor: 5.091

7.  Fitness cost and interference of Arm/Rmt aminoglycoside resistance with the RsmF housekeeping methyltransferases.

Authors:  Belen Gutierrez; Jose A Escudero; Alvaro San Millan; Laura Hidalgo; Laura Carrilero; Cristina M Ovejero; Alfonso Santos-Lopez; Daniel Thomas-Lopez; Bruno Gonzalez-Zorn
Journal:  Antimicrob Agents Chemother       Date:  2012-02-13       Impact factor: 5.191

8.  Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii.

Authors:  Alejandro Beceiro; Antonio Moreno; Nathalie Fernández; Juán A Vallejo; Jesús Aranda; Ben Adler; Marina Harper; John D Boyce; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191

9.  In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator.

Authors:  Antonio Cannatelli; Marco Maria D'Andrea; Tommaso Giani; Vincenzo Di Pilato; Fabio Arena; Simone Ambretti; Paolo Gaibani; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2013-08-26       Impact factor: 5.191

10.  Feedback inhibition in the PhoQ/PhoP signaling system by a membrane peptide.

Authors:  Andrew M Lippa; Mark Goulian
Journal:  PLoS Genet       Date:  2009-12-24       Impact factor: 5.917
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  22 in total

1.  Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.

Authors:  Fabio Arena; Lucia Henrici De Angelis; Antonio Cannatelli; Vincenzo Di Pilato; Marina Amorese; Marco Maria D'Andrea; Tommaso Giani; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

2.  Colistin-resistance-mediated bacterial surface modification sensitizes phage infection.

Authors:  Guijuan Hao; Annie I Chen; Ming Liu; Haijian Zhou; Marisa Egan; Xiaoman Yang; Biao Kan; Hui Wang; Mark Goulian; Jun Zhu
Journal:  Antimicrob Agents Chemother       Date:  2019-09-30       Impact factor: 5.191

3.  Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.

Authors:  Axel B Janssen; Dennis J Doorduijn; Grant Mills; Malbert R C Rogers; Marc J M Bonten; Suzan H M Rooijakkers; Rob J L Willems; Jose A Bengoechea; Willem van Schaik
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

4.  Genotyping of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles.

Authors:  Suely Carlos Ferreira Sampaio; Rozane de Lima Bigelli Carvalho; Marcelo Jenné Mimica; Cely Barreto da Silva; Lycia Mara Jenné Mimica; Aline Valerio de Lima; Keila de Oliveira Lima; Darlan Augusto da Costa Rocha; Jorge Luiz Mello Sampaio
Journal:  Braz J Microbiol       Date:  2021-08-30       Impact factor: 2.214

Review 5.  Causes of polymyxin treatment failure and new derivatives to fill the gap.

Authors:  Selena Chiu; Anna M Hancock; Bob W Schofner; Katherine J Sniezek; Nashaly Soto-Echevarria; Gabrielle Leon; Darshan M Sivaloganathan; Xuanqing Wan; Mark P Brynildsen
Journal:  J Antibiot (Tokyo)       Date:  2022-09-20       Impact factor: 3.424

6.  Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply.

Authors:  Alfonso Santos-Lopez; Melissa J Fritz; Jeffrey B Lombardo; Ansen H P Burr; Victoria A Heinrich; Christopher W Marshall; Vaughn S Cooper
Journal:  Evol Med Public Health       Date:  2022-05-30

7.  Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.

Authors:  Yan Zhu; Irene Galani; Ilias Karaiskos; Jing Lu; Su Mon Aye; Jiayuan Huang; Heidi H Yu; Tony Velkov; Helen Giamarellou; Jian Li
Journal:  J Infect       Date:  2019-07-30       Impact factor: 6.072

8.  MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission.

Authors:  Andrew S Bray; Richard D Smith; Andrew W Hudson; Giovanna E Hernandez; Taylor M Young; Hannah E George; Robert K Ernst; M Ammar Zafar
Journal:  mBio       Date:  2022-03-21       Impact factor: 7.786

9.  In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate.

Authors:  Jlenia Brunetti; Chiara Falciani; Giulia Roscia; Simona Pollini; Stefano Bindi; Silvia Scali; Unai Cossio Arrieta; Vanessa Gómez-Vallejo; Leila Quercini; Elisa Ibba; Marco Prato; Gian Maria Rossolini; Jordi Llop; Luisa Bracci; Alessandro Pini
Journal:  Sci Rep       Date:  2016-05-12       Impact factor: 4.379

10.  Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae.

Authors:  Lisa M Leung; Vaughn S Cooper; David A Rasko; Qinglan Guo; Marissa P Pacey; Christi L McElheny; Roberta T Mettus; Sung Hwan Yoon; David R Goodlett; Robert K Ernst; Yohei Doi
Journal:  J Antimicrob Chemother       Date:  2017-11-01       Impact factor: 5.790
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