Literature DB >> 25691455

The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer's Disease?

Golmaryam Sarlak1,2, Bruno Vincent3,4,5.   

Abstract

Sox2 is a component of the core transcriptional regulatory network which maintains the totipotency of the cells during embryonic preimplantation period, the pluripotency of embryonic stem cells, and the multipotency of neural stem cells. This maintenance is controlled by internal loops between Sox2 and other transcription factors of the core such as Oct4, Nanog, Dax1, and Klf4, downstream proteins of extracellular ligands, epigenetic modifiers, and miRNAs. As Sox2 plays an important role in the balance between stem cells maintenance and commitment to differentiated lineages throughout the lifetime, it is supposed that Sox2 could regulate stem cells aging processes. In this review, we provide an update concerning the involvement of Sox2 in neurogenesis during normal aging and discuss its possible role in Alzheimer's disease.

Entities:  

Keywords:  Aging; Alzheimer’s disease; Neural stem cells; Neurogenesis; Sox2; Transcription factors

Mesh：

Substances：

Year:  2015        PMID： 25691455     DOI： 10.1007/s12035-015-9123-4

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  197 in total

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3.  p53 suppresses the self-renewal of adult neural stem cells.

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Review 4.  α-Secretase in Alzheimer's disease and beyond: mechanistic, regulation and function in the shedding of membrane proteins.

Authors:  Bruno Vincent; Frederic Checler
Journal:  Curr Alzheimer Res       Date:  2012-02       Impact factor: 3.498

5.  Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification.

Authors:  Joana Neves; Carolina Parada; Mireia Chamizo; Fernando Giráldez
Journal:  Development       Date:  2011-02       Impact factor: 6.868

Review 6.  The PKB/FOXO switch in aging and cancer.

Authors:  David E A Kloet; Boudewijn M T Burgering
Journal:  Biochim Biophys Acta       Date:  2011-04-27

7.  Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.

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Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

8.  GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Authors:  Christopher J Phiel; Christina A Wilson; Virginia M-Y Lee; Peter S Klein
Journal:  Nature       Date:  2003-05-22       Impact factor: 49.962

9.  Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells.

Authors:  Prashob Porayette; Miguel J Gallego; Maria M Kaltcheva; Richard L Bowen; Sivan Vadakkadath Meethal; Craig S Atwood
Journal:  J Biol Chem       Date:  2009-06-19       Impact factor: 5.157

10.  HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells.

Authors:  Benjamin L Kidder; Stephen Palmer
Journal:  Nucleic Acids Res       Date:  2011-12-10       Impact factor: 16.971
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  13 in total

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Review 3.  Paradoxical role of SOX2 in gastric cancer.

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4.  nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription.

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Journal:  Development       Date:  2018-01-19       Impact factor: 6.868

6.  SOX Transcription Factors in Endothelial Differentiation and Endothelial-Mesenchymal Transitions.

Authors:  Yucheng Yao; Jiayi Yao; Kristina I Boström
Journal:  Front Cardiovasc Med       Date:  2019-03-28

Review 7.  Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer.

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8.  Autophagy is required for human umbilical cord mesenchymal stem cells to improve spatial working memory in APP/PS1 transgenic mouse model.

Authors:  Wen Li; Kai Li; Jing Gao; Zhuo Yang
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Review 9.  Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.

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10.  The Sox2 transcription factor binds RNA.

Authors:  Zachariah E Holmes; Desmond J Hamilton; Taeyoung Hwang; Nicholas V Parsonnet; John L Rinn; Deborah S Wuttke; Robert T Batey
Journal:  Nat Commun       Date:  2020-04-14       Impact factor: 14.919
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