Frank C van Bussel1, Walter H Backes2, Paul A Hofman1, Robert J van Oostenbrugge3, Alfons G Kessels4, Martin P van Boxtel5, Miranda T Schram6, Coen D Stehouwer6, Joachim E Wildberger7, Jacobus F Jansen8. 1. Department of Radiology, Maastricht University Medical Center, Maastricht, the Netherlands School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands. 2. Department of Radiology, Maastricht University Medical Center, Maastricht, the Netherlands School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands. 3. School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands. 4. Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht, the Netherlands. 5. School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands Department of Psychiatry and Neuropsychology, Maastricht University Medical Center, Maastricht, the Netherlands. 6. Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands. 7. Department of Radiology, Maastricht University Medical Center, Maastricht, the Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands. 8. Department of Radiology, Maastricht University Medical Center, Maastricht, the Netherlands School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands jacobus.jansen@mumc.nl.
Abstract
OBJECTIVE: Type 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODS: Thirty-nine participants with type 2 diabetes (64.5 ± 6.1 years old) and 34 participants without type 2 diabetes (58.3 ± 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTS: For the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONS: In addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.
OBJECTIVE:Type 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODS: Thirty-nine participants with type 2 diabetes (64.5 ± 6.1 years old) and 34 participants without type 2 diabetes (58.3 ± 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTS: For the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONS: In addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.
Authors: S M Wong; W H Backes; C E Zhang; J Staals; R J van Oostenbrugge; C R L P N Jeukens; J F A Jansen Journal: AJNR Am J Neuroradiol Date: 2017-12-07 Impact factor: 3.825
Authors: Frank C G van Bussel; Walter H Backes; Paul A M Hofman; Robert J van Oostenbrugge; Martin P J van Boxtel; Frans R J Verhey; Harry W M Steinbusch; Miranda T Schram; Coen D A Stehouwer; Joachim E Wildberger; Jacobus F A Jansen Journal: Front Neurosci Date: 2017-04-05 Impact factor: 4.677
Authors: Sau May Wong; C Eleana Zhang; Frank C G van Bussel; Julie Staals; Cécile R L P N Jeukens; Paul A M Hofman; Robert J van Oostenbrugge; Walter H Backes; Jacobus F A Jansen Journal: Neuroimage Clin Date: 2017-01-17 Impact factor: 4.881
Authors: Jacobus F A Jansen; Frank C G van Bussel; Harm J van de Haar; Matthias J P van Osch; Paul A M Hofman; Martin P J van Boxtel; Robert J van Oostenbrugge; Miranda T Schram; Coen D A Stehouwer; Joachim E Wildberger; Walter H Backes Journal: Sci Rep Date: 2016-12-05 Impact factor: 4.379
Authors: Maud van Dinther; Paulien Hm Voorter; Jacobus Fa Jansen; Elizabeth Av Jones; Robert J van Oostenbrugge; Julie Staals; Walter H Backes Journal: J Cereb Blood Flow Metab Date: 2022-01-26 Impact factor: 6.960
Authors: Frank C G van Bussel; Walter H Backes; Paul A M Hofman; Nicolaas A J Puts; Richard A E Edden; Martin P J van Boxtel; Miranda T Schram; Coen D A Stehouwer; Joachim E Wildberger; Jacobus F A Jansen Journal: Medicine (Baltimore) Date: 2016-09 Impact factor: 1.889