| Literature DB >> 25688030 |
Jun Yang1, Andrea C Charif2, Judit E Puskas2, Hannah Phillips1, Kaitlyn J Shanahan1, Jessica Garsed1, Aaron Fleischman3, Ken Goldman4, Shuvo Roy, Matthew T Luebbers5, Stephen M Dombrowski1, Mark G Luciano6.
Abstract
This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix(™) is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix(™) has already been shown to be an excellent protective coating for new ICP monitoring chip.Entities:
Keywords: Biocompatibility; Brain implants; Cerebral cortex; Reactivity; Thermoplastic rubber; Toxicity
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Year: 2015 PMID： 25688030 PMCID： PMC4369406 DOI： 10.1016/j.jmbbm.2015.01.018
Source DB: PubMed Journal: J Mech Behav Biomed Mater ISSN： 1878-0180