| Literature DB >> 25687496 |
K E Wood1, E Mantzioris2, R A Gibson1, C E Ramsden3, B S Muhlhausler4.
Abstract
This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty acid (LCPUFA) status in adult humans. The results suggest that it is possible to increase n-3 LCPUFA status by reducing LA and/or increasing ALA intake in humans, although decreasing LA intake to below 2.5%E may be required to specifically increase levels of the n-3 LCPUFA docosahexaenoic acid (DHA). The majority of studies in this area to date have been relatively poor in quality, which limits the ability to draw robust conclusions, and we present a series of recommendations to improve the quality of future studies in fatty acid nutrition in humans.Entities:
Keywords: ALA; DHA; Diet; EPA; Human; LA
Mesh：
Substances：
Year: 2015 PMID： 25687496 PMCID： PMC9406118 DOI： 10.1016/j.plefa.2015.01.001
Source DB: PubMed Journal: Prostaglandins Leukot Essent Fatty Acids ISSN： 0952-3278 Impact factor: 3.015