Tiffany F Hughes1, James T Becker2, Ching-Wen Lee3, Chung-Chou H Chang4, Mary Ganguli5. 1. Department of Psychiatry, University of Pittsburgh, Pittsburgh PA, USA. Electronic address: hughest2@upmc.edu. 2. Department of Psychiatry, University of Pittsburgh, Pittsburgh PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh PA, USA; Department of Psychology, University of Pittsburgh, Pittsburgh PA, USA. 3. Department of Psychiatry, University of Pittsburgh, Pittsburgh PA, USA. 4. Department of Medicine, University of Pittsburgh, Pittsburgh PA, USA; Department of Biostatistics, University of Pittsburgh, Pittsburgh PA, USA. 5. Department of Psychiatry, University of Pittsburgh, Pittsburgh PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh PA, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh PA, USA.
Abstract
INTRODUCTION: The objective of this study was to examine the independent and combined influences of late-life cognitive activity (CA) and physical activity (PA) on the risk of incident mild cognitive impairment (MCI). METHODS: We used interval censored survival modeling to examine the risk of incident MCI (Clinical Dementia Rating [CDR] = 0.5) as a function of CA (high vs. low) and at least moderate intensity PA (any vs. none) among 864 cognitively normal (CDR = 0) older adults. RESULTS: During three annual follow-up waves, 72 participants developed MCI. Compared with low CA with no PA, significant reductions in risk for MCI were observed for high CA with any PA (hazards ratio (HR) = 0.20, 95% confidence interval (CI) 0.07-0.52) and low CA with any PA (HR = 0.52, 95% CI 0.29-0.93), but not for high CA without PA (HR = 0.94, 95% CI 0.45-1.95). DISCUSSION: These findings suggest that a combination of CA and PA may be most efficacious at reducing the risk for cognitive impairment.
INTRODUCTION: The objective of this study was to examine the independent and combined influences of late-life cognitive activity (CA) and physical activity (PA) on the risk of incident mild cognitive impairment (MCI). METHODS: We used interval censored survival modeling to examine the risk of incident MCI (Clinical Dementia Rating [CDR] = 0.5) as a function of CA (high vs. low) and at least moderate intensity PA (any vs. none) among 864 cognitively normal (CDR = 0) older adults. RESULTS: During three annual follow-up waves, 72 participants developed MCI. Compared with low CA with no PA, significant reductions in risk for MCI were observed for high CA with any PA (hazards ratio (HR) = 0.20, 95% confidence interval (CI) 0.07-0.52) and low CA with any PA (HR = 0.52, 95% CI 0.29-0.93), but not for high CA without PA (HR = 0.94, 95% CI 0.45-1.95). DISCUSSION: These findings suggest that a combination of CA and PA may be most efficacious at reducing the risk for cognitive impairment.
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