Literature DB >> 2568449

The transport of microspheres from the gastro-intestinal tract to inflammatory air pouches in the rat.

H O Alpar1, W N Field, R Hyde, D A Lewis.   

Abstract

The distribution of latex microspheres (1.1 microns diam) has been investigated in-vivo, as a potential passive targeted system for the treatment of inflammation. Microspheres administered orally were found in the circulation and in inflamed tissues and exudates of inflammatory air pouches in rats. Oral absorption was also found in a rabbit. Particles administered directly into the circulation also penetrated into the air pouch tissues and fluids. The possibility of using microspheres as a passive targeted system for the treatment of inflammation is discussed.

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Year:  1989        PMID： 2568449     DOI： 10.1111/j.2042-7158.1989.tb06429.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  11 in total

1.  Albumin microspheres as carriers for the antiarthritic drug celecoxib.

Authors:  Hetal Thakkar; Rakesh Kumar Sharma; Anil Kumar Mishra; Krishna Chuttani; Rayasa Ramchandra Murthy
Journal:  AAPS PharmSciTech       Date:  2005-09-20       Impact factor: 3.246

2.  The effect of size on uptake of orally administered latex microparticles in the small intestine and transport to mesenteric lymph nodes.

Authors:  K E Carr; R A Hazzard; S Reid; G M Hodges
Journal:  Pharm Res       Date:  1996-08       Impact factor: 4.200

3.  Gastrointestinal uptake of biodegradable microparticles: effect of particle size.

Authors:  M P Desai; V Labhasetwar; G L Amidon; R J Levy
Journal:  Pharm Res       Date:  1996-12       Impact factor: 4.200

4.  Early intestinal microparticle uptake in the rat.

Authors:  R A Hazzard; G M Hodges; J D Scott; C B McGuinness; K E Carr
Journal:  J Anat       Date:  1996-10       Impact factor: 2.610

5.  Uptake and translocation of microparticles in small intestine. Morphology and quantification of particle distribution.

Authors:  G M Hodges; E A Carr; R A Hazzard; K E Carr
Journal:  Dig Dis Sci       Date:  1995-05       Impact factor: 3.199

6.  Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells.

Authors:  M A Jepson; N L Simmons; T C Savidge; P S James; B H Hirst
Journal:  Cell Tissue Res       Date:  1993-03       Impact factor: 5.249

Review 7.  Drug targeting with nanoparticles.

Authors:  J Kreuter
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Jul-Sep       Impact factor: 2.441

8.  Intestinal absorption of PLAGA microspheres in the rat.

Authors:  C Damgé; M Aprahamian; H Marchais; J P Benoit; M Pinget
Journal:  J Anat       Date:  1996-12       Impact factor: 2.610

9.  Effect of animal age on the uptake of large particulates across the epithelium of the rat small intestine.

Authors:  L Simon; G Shine; A D Dayan
Journal:  Int J Exp Pathol       Date:  1994-10       Impact factor: 1.925

10.  Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres.

Authors:  Joshua J Reineke; Daniel Y Cho; Yu-Ting Dingle; A Peter Morello; Jules Jacob; Christopher G Thanos; Edith Mathiowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-06       Impact factor: 11.205
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