Literature DB >> 2568330

A genetic linkage map of 17 markers on human chromosome 21.

A C Warren1, S A Slaugenhaupt, J G Lewis, A Chakravarti, S E Antonarakis.   

Abstract

We have constructed a genetic linkage map of 17 markers on the long arm of human chromosome 21, including six genes and two anonymous loci with a variable number of tandem repeats. The estimated length of the map is 103 cM in males and 140 cM in females, assuming Kosambi interference. Recombination in females was approximately twice that in males between proximal markers. However, over half of the recombination events in either sex occur distally, in 21q22.3, although this region accounts for only about 15% of the physical length of chromosome 21.

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Year:  1989        PMID： 2568330     DOI： 10.1016/0888-7543(89)90282-6

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  21 in total

1.  DNA polymorphism analysis in families with recurrence of free trisomy 21.

Authors:  C G Pangalos; C C Talbot; J G Lewis; P A Adelsberger; M B Petersen; J L Serre; M O Rethoré; M C de Blois; P Parent; A A Schinzel
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

2.  No evidence for a paternal interchromosomal effect from analysis of the origin of nondisjunction in Down syndrome patients with concomitant familial chromosome rearrangements.

Authors:  A A Schinzel; P A Adelsberger; F Binkert; S Basaran; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

3.  A contiguous Not I restriction map of band q22.3 of human chromosome 21.

Authors:  D Wang; H Fang; C R Cantor; C L Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

4.  Cytogenetic and molecular analysis of a de novo tandem duplication of chromosome 21.

Authors:  J L Blouin; A Aurias; N Créau-Goldberg; F Apiou; C Alcaide-Loridan; A Bruel; M Prieur; J Kraus; J M Delabar; P M Sinet
Journal:  Hum Genet       Date:  1991-12       Impact factor: 4.132

5.  A molecular genetic approach to the identification of isochromosomes of chromosome 21.

Authors:  L G Shaffer; C K Jackson-Cook; J M Meyer; J A Brown; J E Spence
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

6.  The COL6A1 and COL6A2 genes exist as a gene cluster and detect highly informative DNA polymorphisms in the telomeric region of human chromosome 21q.

Authors:  C A Francomano; G R Cutting; M K McCormick; M L Chu; R Timpl; H K Hong; S E Antonarakis
Journal:  Hum Genet       Date:  1991-06       Impact factor: 4.132

7.  Trisomy 21: association between reduced recombination and nondisjunction.

Authors:  S L Sherman; N Takaesu; S B Freeman; M Grantham; C Phillips; R D Blackston; P A Jacobs; A E Cockwell; V Freeman; I Uchida
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

8.  Analysis of DNA polymorphisms suggests that most de novo dup(21q) chromosomes in patients with Down syndrome are isochromosomes and not translocations.

Authors:  S E Antonarakis; P A Adelsberger; M B Petersen; F Binkert; A A Schinzel
Journal:  Am J Hum Genet       Date:  1990-12       Impact factor: 11.025

9.  Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16.

Authors:  J Pash; N Popescu; M Matocha; S Rapoport; M Bustin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

10.  Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22.

Authors:  A E Lehesjoki; M Koskiniemi; P Sistonen; J Miao; J Hästbacka; R Norio; A de la Chapelle
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205
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