Literature DB >> 25683004

miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8.

Yan Yan1, Qin Wang2, Xiao-Ling Yan2, Yi Zhang3, Wei Li2, Fan Tang2, Xu Li2, Ping Yang2.   

Abstract

MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 (EphA8). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced by miR-10a. We further demonstrate that miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect cell migration and invasion. Collectively, we unveil a branch of the miR-10a/EphA8 pathway that regulates the progression of glioma.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Eph tyrosine kinase receptor A8; Epithelial–mesenchymal transition; Glioma; Invasion; MicroRNAs; Migration

Mesh：

Substances：

Year:  2015        PMID： 25683004     DOI： 10.1016/j.febslet.2015.02.005

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  30 in total

Review 1.  The role of EMT and MET in cancer dissemination.

Authors:  Jacqueline Banyard; Diane R Bielenberg
Journal:  Connect Tissue Res       Date:  2015-08-20       Impact factor: 3.417

2.  Expression of microRNAs in tumors of the central nervous system in pediatric patients in México.

Authors:  Pilar Eguía-Aguilar; Lisette Gutiérrez-Castillo; Mario Pérezpeña-Díazconti; Jeanette García-Chéquer; Jorge García-Quintana; Fernando Chico-Ponce de León; Luis Gordillo-Domínguez; Samuel Torres-García; Francisco Arenas-Huertero
Journal:  Childs Nerv Syst       Date:  2017-08-16       Impact factor: 1.475

3.  Low MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in glioma.

Authors:  Liang Xue; Yi Wang; Shuyuan Yue; Jianning Zhang
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

4.  Stem-like Cells from Invasive Breast Carcinoma Cell Line MDA-MB-231 Express a Distinct Set of Eph Receptors and Ephrin Ligands.

Authors:  Mariana Lucero; Jaspreet Thind; Jacqueline Sandoval; Shayan Senaati; Belinda Jimenez; Raj P Kandpal
Journal:  Cancer Genomics Proteomics       Date:  2020 Nov-Dec       Impact factor: 4.069

5.  miR-503 inhibits cell proliferation and invasion in glioma by targeting L1CAM.

Authors:  Hao Liu; Zhi Song; Daguang Liao; Tianyi Zhang; Feng Liu; Wen Zheng; Kui Luo; Liang Yang
Journal:  Int J Clin Exp Med       Date:  2015-10-15

6.  TUSC7 acts as a tumor suppressor in colorectal cancer.

Authors:  Weidan Ren; Shuo Chen; Guiwei Liu; Xuesong Wang; Haopeng Ye; Yanguo Xi
Journal:  Am J Transl Res       Date:  2017-09-15       Impact factor: 4.060

7.  Artesunate-induced Cellular Effects Are Mediated by Specific EPH Receptors and Ephrin Ligands in Breast Carcinoma Cells.

Authors:  Tanin Zadeh; Mariana Lucero; Raj P Kandpal
Journal:  Cancer Genomics Proteomics       Date:  2022 Jan-Feb       Impact factor: 4.069

8.  Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion.

Authors:  Zhiqiang Xia; Fang Liu; Jian Zhang; Li Liu
Journal:  PLoS One       Date:  2015-07-02       Impact factor: 3.240

9.  The Expression Profile and Prognostic Values of EPHA Family Members in Breast Cancer.

Authors:  Xixun Zhang
Journal:  Front Oncol       Date:  2021-06-18       Impact factor: 6.244

10.  Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2.

Authors:  Yuan Rong; Chun-Hui Yuan; Zhen Qu; Hu Zhou; Qing Guan; Na Yang; Xiao-Hua Leng; Lang Bu; Ke Wu; Fu-Bing Wang
Journal:  Sci Rep       Date:  2016-04-01       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.