Association between red blood cell distribution and renal function in patients with untreated type 2 diabetes mellitus.

We assessed whether red cell distribution width (RDW) is associated with microalbuminuria (MAU) in a group of 320 patients with newly diagnosed type 2 diabetes mellitus (T2DM), recruited in Zhengzhou. Patients were divided into normal group and MAU group. Compared with the normal group, the patients with MAU had higher red blood cell count (p = 0.005) and RDW (p < 0.001). The multiple logistic regression indicated that RDW (OR = 3.89, 95% CI: 1.98-7.66, p < 0.001) was an independent risk factor of MAU in newly diagnosed T2DM. Other factors include smoking (OR = 4.44, 95% CI: 2.90-8.72, p < 0.001), higher waist index (OR = 2.17, 95% CI: 1.89-5.26, p = 0.002), FBG level (OR = 2.05, 95% CI: 1.21-3.84, p = 0.008) and uric acid level (OR = 2.18, 95% CI: 1.05-4.52, p = 0.037). The receiver operating characteristic (ROC) curves explored the relationship between MAU and RDW. The area under the curve was 0.79 (95% CI: 0.74-0.84; p < 0.001). Using a cut-off point of 12.8, the RDW predicted MAU in the T2DM patients with a sensitivity of 71.3% and specificity of 66.9%. RDW may be independently associated with MAU in patients with newly diagnosed T2DM. RDW may be treated as effective predictive index in the evaluation of diabetes nephropathy or diabetes-associated complications.