Sophie Penning1, Chris Pretty2, Jean-Charles Preiser3, Geoffrey M Shaw4, Thomas Desaive5, J Geoffrey Chase6. 1. GIGA-Cardiovascular Sciences, Institut de Physique, Université de Liege, Institut de Physics, Allée du 6 Août, 17 (Bât B5), B4000 Liege, Liege, Belgium. Electronic address: Sophie.Penning@ulg.ac.be. 2. Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Private Bag 4800, Christchurch 8054, New Zealand. Electronic address: chris.pretty@canterbury.ac.nz. 3. Department of Intensive Care, Erasme University Hospital, 808 route de Lennik, B1070 Brussels, Belgium. Electronic address: Jean-Charles.Preiser@erasme.ulb.ac.be. 4. School of Medicine, University of Otago Christchurch, Christchurch 8054, New Zealand; Department of Intensive Care, Christchurch Hospital, Christchurch 8054, New Zealand. Electronic address: geoff.shaw@cdhb.govt.nz. 5. GIGA-Cardiovascular Sciences, Institut de Physique, Université de Liege, Institut de Physics, Allée du 6 Août, 17 (Bât B5), B4000 Liege, Liege, Belgium. Electronic address: tdesaive@ulg.ac.be. 6. Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Private Bag 4800, Christchurch 8054, New Zealand. Electronic address: geoff.chase@canterbury.ac.nz.
Abstract
OBJECTIVE: The goal of this research is to demonstrate that well-regulated glycemia is beneficial to patient outcome, regardless of how it is achieved. METHODS: This analysis used data from 1701 patients from 2, independent studies. Glycemic outcome was measured using cumulative time in band (cTIB), calculated for 3 glycemic bands and for threshold values of t = 0.5, 0.6, 0.7, and 0.8. For each day of intensive care unit stay, patients were classified by cTIB, threshold, and hospital mortality, and odds of living (OL) and odds ratio were calculated. RESULTS: The OL given cTIB ≥ t is higher than the OL given cTIB <t for all values of t, every day, for all 3 glycemic bands studied. The difference between the odds clearly increased over intensive care unit stay for t>0.6. Higher cTIB thresholds resulted in larger increases to odds ratio over time and were particularly significant for the 4.0 to 7.0 mmol/L glycemic band. CONCLUSION: Increased cTIB was associated with higher OL. These results suggest that effective glycemic control positively influences patient outcome, regardless of how the glycemic regulation is achieved. Blood glucose < 7.0 mmol/L is associated with a measurable increase in the odds of survival, if hypoglycemia is avoided.
OBJECTIVE: The goal of this research is to demonstrate that well-regulated glycemia is beneficial to patient outcome, regardless of how it is achieved. METHODS: This analysis used data from 1701 patients from 2, independent studies. Glycemic outcome was measured using cumulative time in band (cTIB), calculated for 3 glycemic bands and for threshold values of t = 0.5, 0.6, 0.7, and 0.8. For each day of intensive care unit stay, patients were classified by cTIB, threshold, and hospital mortality, and odds of living (OL) and odds ratio were calculated. RESULTS: The OL given cTIB ≥ t is higher than the OL given cTIB <t for all values of t, every day, for all 3 glycemic bands studied. The difference between the odds clearly increased over intensive care unit stay for t>0.6. Higher cTIB thresholds resulted in larger increases to odds ratio over time and were particularly significant for the 4.0 to 7.0 mmol/L glycemic band. CONCLUSION: Increased cTIB was associated with higher OL. These results suggest that effective glycemic control positively influences patient outcome, regardless of how the glycemic regulation is achieved. Blood glucose < 7.0 mmol/L is associated with a measurable increase in the odds of survival, if hypoglycemia is avoided.
Authors: Jean-Charles Preiser; J Geoffrey Chase; Roman Hovorka; Jeffrey I Joseph; James S Krinsley; Christophe De Block; Thomas Desaive; Luc Foubert; Pierre Kalfon; Ulrike Pielmeier; Tom Van Herpe; Jan Wernerman Journal: J Diabetes Sci Technol Date: 2016-11-01
Authors: Athirah Abdul Razak; Asma Abu-Samah; Normy Norfiza Abdul Razak; Ummu Jamaludin; Fatanah Suhaimi; Azrina Ralib; Mohd Basri Mat Nor; Christopher Pretty; Jennifer Laura Knopp; James Geoffrey Chase Journal: Med Devices (Auckl) Date: 2020-06-04
Authors: Vincent Uyttendaele; Jennifer L Dickson; Geoffrey M Shaw; Thomas Desaive; J Geoffrey Chase Journal: Crit Care Date: 2017-06-24 Impact factor: 9.097
Authors: J Geoffrey Chase; Jean-Charles Preiser; Jennifer L Dickson; Antoine Pironet; Yeong Shiong Chiew; Christopher G Pretty; Geoffrey M Shaw; Balazs Benyo; Knut Moeller; Soroush Safaei; Merryn Tawhai; Peter Hunter; Thomas Desaive Journal: Biomed Eng Online Date: 2018-02-20 Impact factor: 2.819
Authors: J Geoffrey Chase; Thomas Desaive; Julien Bohe; Miriam Cnop; Christophe De Block; Jan Gunst; Roman Hovorka; Pierre Kalfon; James Krinsley; Eric Renard; Jean-Charles Preiser Journal: Crit Care Date: 2018-08-02 Impact factor: 9.097