Maria P Vélez1, Tye E Arbuckle2, William D Fraser3. 1. Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, Quebec, Canada. Electronic address: mdp.velez.gomez@umontreal.ca. 2. Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada. 3. Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, Quebec, Canada.
Abstract
OBJECTIVE: To assess the potential effect of bisphenol A (BPA), triclosan (TCS), and phthalates on women's fecundity, as measured by time to pregnancy (TTP). DESIGN: Pregnancy-based retrospective TTP study. SETTING: Not applicable. PATIENT(S): A total of 2,001 women during the first trimester of pregnancy recruited between 2008 and 2011 (the Maternal-Infant Research on Environmental Chemicals (MIREC) Study), with 1,742 women included in the BPA analysis, 1,699 in the TCS analysis, and 1,597 in the phthalates analysis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Fecundability odds ratios (FORs) estimated using the Cox model modified for discrete time data. RESULT(S): The BPA concentrations were not statistically significantly associated with diminished fecundity either in crude or adjusted models. Women in the highest quartile of TCS (>72 ng/mL) had evidence of decreased fecundity (FOR 0.84; 95% confidence interval, 0.72-0.97) compared with the three lower quartiles as the reference group. Exposure to phthalates was suggestive of a shorter TTP, as indicated by FORs greater than 1, although the 95% confidence interval always included 1. CONCLUSION(S): Elevated TCS exposure may be associated with diminished fecundity. BPA and phthalates showed no negative impact; on the contrary, some phthalates might be associated with a shorter time to pregnancy. A major limitation of the study was that only one measurement of exposure was available for each woman after conception. Further research is necessary to test these findings.
OBJECTIVE: To assess the potential effect of bisphenol A (BPA), triclosan (TCS), and phthalates on women's fecundity, as measured by time to pregnancy (TTP). DESIGN: Pregnancy-based retrospective TTP study. SETTING: Not applicable. PATIENT(S): A total of 2,001 women during the first trimester of pregnancy recruited between 2008 and 2011 (the Maternal-Infant Research on Environmental Chemicals (MIREC) Study), with 1,742 women included in the BPA analysis, 1,699 in the TCS analysis, and 1,597 in the phthalates analysis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Fecundability odds ratios (FORs) estimated using the Cox model modified for discrete time data. RESULT(S): The BPA concentrations were not statistically significantly associated with diminished fecundity either in crude or adjusted models. Women in the highest quartile of TCS (>72 ng/mL) had evidence of decreased fecundity (FOR 0.84; 95% confidence interval, 0.72-0.97) compared with the three lower quartiles as the reference group. Exposure to phthalates was suggestive of a shorter TTP, as indicated by FORs greater than 1, although the 95% confidence interval always included 1. CONCLUSION(S): Elevated TCS exposure may be associated with diminished fecundity. BPA and phthalates showed no negative impact; on the contrary, some phthalates might be associated with a shorter time to pregnancy. A major limitation of the study was that only one measurement of exposure was available for each woman after conception. Further research is necessary to test these findings.
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