| Literature DB >> 25681723 |
Lei Zhao1, Yanxia Zhou1, Yajie Gao1, Shujin Ma1, Chao Zhang1, Jinwen Li1, Dishi Wang1, Xueping Li1, Chengwei Li1, Yan Liu2, Xinru Li3.
Abstract
The purpose of the present study was to develop a new nanoparticulate formulation for delivery of tacrolimus to reduce its kidney distribution and functional nephrotoxicity. Tacrolimus (TAC)-loaded bovine serum albumin (BSA) nanoparticles (TAC-BSA-NPs) were prepared by emulsification-dispersion technique. The obtained TAC-BSA-NPs, with 189.50±7.15 nm of diameter and -20.86±0.45 mV of Zeta potential determined by DLS, were spherical in shape observed by TEM. The drug loading content and encapsulation efficiency were (1.7±0.13)% and (85±3.0)%, respectively. The in vitro release of TAC-BSA-NPs exhibited biphasic drug release pattern with an initial burst release and subsequently sustained release. Pharmacokinetic analysis displayed that TAC-BSA-NPs could enhance the drug blood level and prolong the circulation time in comparison to Prograf(®). Meanwhile, compared with Prograf(®), TAC-BSA-NPs could deliver less TAC to kidney and simultaneously reduce the functional nephrotoxicity of TAC to kidney. In conclusion, BSA nanoparticles might be a more safe carrier for delivery of hydrophobic drug TAC.Entities:
Keywords: Bovine serum albumin nanoparticles; Nephrotoxicity; Pharmacokinetics; Tacrolimus; Tissue distribution
Mesh：
Substances：
Year: 2015 PMID： 25681723 DOI： 10.1016/j.ijpharm.2015.02.018
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875