Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Alteration of WWOX in human cancer: a clinical view.

Literature DB >> 25681467

Alteration of WWOX in human cancer: a clinical view.

Izabela Baryła¹, Ewa Styczeń-Binkowska¹, Andrzej K Bednarek².

Abstract

WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3-24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.

Entities: Disease Gene Species

Keywords: WWOX; cancer; tumor suppressor gene

Mesh：

Substances：

Year: 2015 PMID： 25681467 PMCID： PMC4935223 DOI： 10.1177/1535370214561953

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

105 in total

1. Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.

Authors: Dimitrios Iliopoulos; Muller Fabbri; Teresa Druck; Haiyan R Qin; Shuang-Yin Han; Kay Huebner
Journal: Clin Cancer Res Date: 2007-01-01 Impact factor: 12.531

Review 2. WWOX gene and gene product: tumor suppression through specific protein interactions.

Authors: Zaidoun Salah; Rami Aqeilan; Kay Huebner
Journal: Future Oncol Date: 2010-02 Impact factor: 3.404

3. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

Authors: A K Bednarek; K J Laflin; R L Daniel; Q Liao; K A Hawkins; C M Aldaz
Journal: Cancer Res Date: 2000-04-15 Impact factor: 12.701

4. Cloning of WWOX gene and its growth-inhibiting effects on ovarian cancer cells.

Authors: Zhoufang Xiong; Sha Hu; Zehua Wang
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2010-06-17

5. WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.

Authors: Sai Yendamuri; Tamotsu Kuroki; Francesco Trapasso; Adam C Henry; Kristoffel R Dumon; Kay Huebner; Noel N Williams; Larry R Kaiser; Carlo M Croce
Journal: Cancer Res Date: 2003-02-15 Impact factor: 12.701

6. Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients.

Authors: Anna Göthlin Eremo; Pia Wegman; Olle Stål; Bo Nordenskjöld; Tommy Fornander; Sten Wingren
Journal: Oncol Rep Date: 2013-01-31 Impact factor: 3.906

Review 7. Alterations of common chromosome fragile sites in hematopoietic malignancies.

Authors: Hideshi Ishii; Yusuke Furukawa
Journal: Int J Hematol Date: 2004-04 Impact factor: 2.490

8. The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.

Authors: Ghada Abdel-Salam; Michaela Thoenes; Hanan H Afifi; Friederike Körber; Daniel Swan; Hanno Jörn Bolz
Journal: Orphanet J Rare Dis Date: 2014-01-23 Impact factor: 4.123

9. Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy.

Authors: Z Salah; T Bar-mag; Y Kohn; F Pichiorri; T Palumbo; G Melino; R I Aqeilan
Journal: Cell Death Dis Date: 2013-01-31 Impact factor: 8.469

Review 10. Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors.

Authors: Juan Li; Jie Liu; Yu Ren; Jin Yang; Peijun Liu
Journal: Int J Biol Sci Date: 2014-01-11 Impact factor: 6.580

14 in total

1. Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.

Authors: Yingchang Lu; Sun-Seog Kweon; Chizu Tanikawa; Wei-Hua Jia; Yong-Bing Xiang; Qiuyin Cai; Chenjie Zeng; Stephanie L Schmit; Aesun Shin; Keitaro Matsuo; Sun Ha Jee; Dong-Hyun Kim; Jeongseon Kim; Wanqing Wen; Jiajun Shi; Xingyi Guo; Bingshan Li; Nan Wang; Ben Zhang; Xinxiang Li; Min-Ho Shin; Hong-Lan Li; Zefang Ren; Jae Hwan Oh; Isao Oze; Yoon-Ok Ahn; Keum Ji Jung; David V Conti; Fredrick R Schumacher; Gad Rennert; Mark A Jenkins; Peter T Campbell; Michael Hoffmeister; Graham Casey; Stephen B Gruber; Jing Gao; Yu-Tang Gao; Zhi-Zhong Pan; Yoichiro Kamatani; Yi-Xin Zeng; Xiao-Ou Shu; Jirong Long; Koichi Matsuda; Wei Zheng
Journal: Gastroenterology Date: 2018-12-06 Impact factor: 22.682

Review 2. Fragile sites in cancer: more than meets the eye.

Authors: Thomas W Glover; Thomas E Wilson; Martin F Arlt
Journal: Nat Rev Cancer Date: 2017-07-25 Impact factor: 60.716

Review 3. Molecular Functions of WWOX Potentially Involved in Cancer Development.

Authors: Karim Taouis; Keltouma Driouch; Rosette Lidereau; François Lallemand
Journal: Cells Date: 2021-04-29 Impact factor: 6.600

Review 4. MicroRNAs Involved in Small-cell Lung Cancer as Possible Agents for Treatment and Identification of New Targets.

Authors: Ulrich H Weidle; Adam Nopora
Journal: Cancer Genomics Proteomics Date: 2021 Sep-Oct Impact factor: 4.069

5. Genetic association study identifies a functional CNV in the WWOX gene contributes to the risk of intracranial aneurysms.

Authors: Jin Fan; Wen Sun; Min Lin; Ke Yu; Jian Wang; Dan Duan; Bo Zheng; Zhenghui Yang; Qingsong Wang
Journal: Oncotarget Date: 2016-03-29

6. A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells.

Authors: Wenxian Tong; Liu Yang; Qiang Yu; Jie Yao; Anbing He
Journal: Onco Targets Ther Date: 2017-02-27 Impact factor: 4.147