Literature DB >> 33946771

Molecular Functions of WWOX Potentially Involved in Cancer Development.

Karim Taouis1, Keltouma Driouch1, Rosette Lidereau1, François Lallemand1.   

Abstract

The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

Entities:  

Keywords:  WWOX; cancers; molecular functions

Year:  2021        PMID： 33946771     DOI： 10.3390/cells10051051

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  110 in total

Review 1.  TGF-β Family Signaling in Tumor Suppression and Cancer Progression.

Authors:  Joan Seoane; Roger R Gomis
Journal:  Cold Spring Harb Perspect Biol       Date:  2017-12-01       Impact factor: 10.005

2.  Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.

Authors:  Nupam P Mahajan; Young E Whang; James L Mohler; H Shelton Earp
Journal:  Cancer Res       Date:  2005-11-15       Impact factor: 12.701

3.  WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

Authors:  A K Bednarek; K J Laflin; R L Daniel; Q Liao; K A Hawkins; C M Aldaz
Journal:  Cancer Res       Date:  2000-04-15       Impact factor: 12.701

4.  Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia.

Authors:  Hsin-Ping Lin; Jean-Yun Chang; Sing-Ru Lin; Ming-Hui Lee; Shenq-Shyang Huang; Li-Jin Hsu; Nan-Shan Chang
Journal:  Genes Cancer       Date:  2011-05

5.  Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours.

Authors:  D Ramos; M Abba; J A López-Guerrero; J Rubio; E Solsona; S Almenar; A Llombart-Bosch; C M Aldaz
Journal:  Histopathology       Date:  2008-04-29       Impact factor: 5.087

6.  Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses.

Authors:  Nan-Shan Chang; Joan Doherty; Amy Ensign; Jennifer Lewis; John Heath; Lori Schultz; Shur-Tzu Chen; Udo Oppermann
Journal:  Biochem Pharmacol       Date:  2003-10-15       Impact factor: 5.858

7.  Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival.

Authors:  J M W Gee; J J Eloranta; J C Ibbitt; J F R Robertson; I O Ellis; T Williams; R I Nicholson; H C Hurst
Journal:  J Pathol       Date:  2009-01       Impact factor: 7.996

8.  Wwox and Ap2gamma expression levels predict tamoxifen response.

Authors:  Gulnur Guler; Dimitrios Iliopoulos; Nilufer Guler; Cigdem Himmetoglu; Mutlu Hayran; Kay Huebner
Journal:  Clin Cancer Res       Date:  2007-10-15       Impact factor: 12.531

Review 9.  WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders.

Authors:  C Marcelo Aldaz; Tabish Hussain
Journal:  Int J Mol Sci       Date:  2020-11-24       Impact factor: 5.923

10.  WWOX modulates the ATR-mediated DNA damage checkpoint response.

Authors:  Mohammad Abu-Odeh; Nyla A Hereema; Rami I Aqeilan
Journal:  Oncotarget       Date:  2016-01-26
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  3 in total

1.  Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2α and AP-2γ Transcription Factors in Bladder Cancer.

Authors:  Damian Kołat; Żaneta Kałuzińska; Andrzej K Bednarek; Elżbieta Płuciennik
Journal:  Cells       Date:  2022-04-19       Impact factor: 7.666

Review 2.  WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners.

Authors:  Tsung-Yun Liu; Ganesan Nagarajan; Ming-Fu Chiang; Shenq-Shyang Huang; Tzu-Chia Lin; Yu-An Chen; Chun-I Sze; Nan-Shan Chang
Journal:  Cells       Date:  2022-07-07       Impact factor: 7.666

3.  Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan.

Authors:  Ju-Pi Li; Jinghua Tsai Chang; Po-Chung Ju; Ming-Hong Hsieh; Yu-Hua Chao; Thomas Chang-Yao Tsao; Ming-Ju Hsieh; Shun-Fa Yang
Journal:  Int J Environ Res Public Health       Date:  2021-12-13       Impact factor: 3.390
  3 in total

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