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Literature DB >> 2567871

Galactose consumption and metabolism in relation to the risk of ovarian cancer.

D W Cramer¹, B L Harlow, W C Willett, W R Welch, D A Bell, R E Scully, W G Ng, R C Knapp.

Abstract

In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1.17 compared with 0.98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.

Entities: Chemical Disease Gene Species

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Year: 1989 PMID： 2567871 DOI： 10.1016/s0140-6736(89)90313-9

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

17 in total

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10. Self-reported use of antidepressants or benzodiazepine tranquilizers and risk of epithelial ovarian cancer: evidence from two combined case-control studies (Massachusetts, United States).

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Galactose consumption and metabolism in relation to the risk of ovarian cancer.

Review 1. Kefir: a powerful probiotics with anticancer properties.

2. Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk.

Review 3. Racial bias in federal nutrition policy, Part I: The public health implications of variations in lactase persistence.

4. Incidence trends for cancers of the breast, ovary, and corpus uteri in urban Shanghai, 1972-89.

Review 5. Pharmacoeconomic considerations in treating ovarian cancer.

6. Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes.

7. Dairy food and nutrient intake in different life periods in relation to risk of ovarian cancer.

8. Dietary lactose intake, lactose intolerance, and the risk of epithelial ovarian cancer in southern Ontario (Canada).

9. Kefir induces apoptosis and inhibits cell proliferation in human acute erythroleukemia.

10. Self-reported use of antidepressants or benzodiazepine tranquilizers and risk of epithelial ovarian cancer: evidence from two combined case-control studies (Massachusetts, United States).