OBJECTIVE: To investigate whether galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk, and to determine if this association was modified by lactose intake. DESIGN: Two prospective cohort studies and a case-control study. SETTING: Academic institution. PATIENT(S): A total of 992 cases and 1,050 population-based control samples from a New England case-control study and 240 cases and 900 control samples from the Nurses' Health Studies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT with the use of the Taqman 5' nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2). RESULT(S): Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled risk ratio 1.1 [95% confidence interval (CI) 0.8-1.5] for D1 and 1.0 [95% CI 0.7-1.4] for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake. CONCLUSION(S): D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.
OBJECTIVE: To investigate whether galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk, and to determine if this association was modified by lactose intake. DESIGN: Two prospective cohort studies and a case-control study. SETTING: Academic institution. PATIENT(S): A total of 992 cases and 1,050 population-based control samples from a New England case-control study and 240 cases and 900 control samples from the Nurses' Health Studies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT with the use of the Taqman 5' nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2). RESULT(S): Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled risk ratio 1.1 [95% confidence interval (CI) 0.8-1.5] for D1 and 1.0 [95% CI 0.7-1.4] for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake. CONCLUSION(S): D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.
Authors: D W Cramer; E R Greenberg; L Titus-Ernstoff; R F Liberman; W R Welch; E Li; W G Ng Journal: Cancer Epidemiol Biomarkers Prev Date: 2000-01 Impact factor: 4.254
Authors: Marc T Goodman; Anna H Wu; Ko-Hui Tung; Katharine McDuffie; Daniel W Cramer; Lynne R Wilkens; Keith Terada; Juergen K V Reichardt; Won G Ng Journal: Am J Epidemiol Date: 2002-10-15 Impact factor: 4.897
Authors: Wendy Cozen; Ruth Peters; Juergen K V Reichardt; Won Ng; Juan C Felix; Peggy Wan; Malcolm C Pike Journal: Cancer Causes Control Date: 2002-03 Impact factor: 2.506
Authors: W L Alan Fung; Harvey Risch; John McLaughlin; Barry Rosen; David Cole; Danny Vesprini; Steven A Narod Journal: Cancer Epidemiol Biomarkers Prev Date: 2003-07 Impact factor: 4.254