Yusuke Murakami1, Noriko Yoshida1, Yasuhiro Ikeda2, Shunji Nakatake1, Kota Fujiwara3, Shoji Notomi1, Takahiro Nabeshima1, Shintaro Nakao1, Toshio Hisatomi1, Hiroshi Enaida4, Tatsuro Ishibashi1. 1. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 2. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: ymocl@pathol1.med.kyushu-u.ac.jp. 3. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan. 4. Department of Ophthalmology, Saga University Faculty of Medicine, Saga, Japan.
Abstract
PURPOSE: To investigate the correlation between aqueous flare values and central visual function in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, observational case series. METHODS: We retrospectively studied 160 patients diagnosed with typical RP and 59 control subjects. Aqueous flare values were measured by laser flare cell meter. The relationships between aqueous flare and best-corrected visual acuity (VA) and mean deviation (MD) of static perimetry tests were analyzed in RP patients. RESULTS: The aqueous flare values were significantly higher in the RP patients compared to the control subjects (10.6 ± 7.9 vs 5.0 ± 2.1 photon counts per millisecond [pc/ms], P < .0001). In the RP patients, the aqueous flare values were negatively correlated with VA (r = 0.359, P < .0001) and MD (r = -0.330, P < .0001). Age-subgroup analysis showed a significant correlation between aqueous flare and VA in the RP patients' 40s, 50s, and 60s and between aqueous flare and MD in the 30s, 40s, 50s, and 60s. The RP patients with MD values ≥-15 decibels (dB) showed significantly higher levels of aqueous flare than those with MD values <-15 dB (12.0 ± 6.2 vs 8.7 ± 5.8, P = .0001). CONCLUSIONS: Aqueous flare is increased in RP patients and negatively correlates with central visual function. These results suggest a close relationship between inflammation and central vision loss in RP.
PURPOSE: To investigate the correlation between aqueous flare values and central visual function in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, observational case series. METHODS: We retrospectively studied 160 patients diagnosed with typical RP and 59 control subjects. Aqueous flare values were measured by laser flare cell meter. The relationships between aqueous flare and best-corrected visual acuity (VA) and mean deviation (MD) of static perimetry tests were analyzed in RP patients. RESULTS: The aqueous flare values were significantly higher in the RP patients compared to the control subjects (10.6 ± 7.9 vs 5.0 ± 2.1 photon counts per millisecond [pc/ms], P < .0001). In the RP patients, the aqueous flare values were negatively correlated with VA (r = 0.359, P < .0001) and MD (r = -0.330, P < .0001). Age-subgroup analysis showed a significant correlation between aqueous flare and VA in the RP patients' 40s, 50s, and 60s and between aqueous flare and MD in the 30s, 40s, 50s, and 60s. The RP patients with MD values ≥-15 decibels (dB) showed significantly higher levels of aqueous flare than those with MD values <-15 dB (12.0 ± 6.2 vs 8.7 ± 5.8, P = .0001). CONCLUSIONS: Aqueous flare is increased in RP patients and negatively correlates with central visual function. These results suggest a close relationship between inflammation and central vision loss in RP.
Authors: Dulce Lima Cunha; Rose Richardson; Dhani Tracey-White; Alessandro Abbouda; Andreas Mitsios; Verena Horneffer-van der Sluis; Panteleimon Takis; Nicholas Owen; Jane Skinner; Ailsa A Welch; Mariya Moosajee Journal: JCI Insight Date: 2021-05-10
Authors: Y Murakami; Y Ikeda; S Nakatake; T Tachibana; K Fujiwara; N Yoshida; S Notomi; S Nakao; T Hisatomi; J W Miller; D G Vavvas; K H Sonoda; T Ishibashi Journal: Cell Death Discov Date: 2015-11-30
Authors: Y Murakami; Y Ikeda; S Nakatake; J W Miller; D G Vavvas; K H Sonoda; T Ishibashi Journal: Cell Death Dis Date: 2015-12-31 Impact factor: 8.469