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Literature DB >> 25676875

MDA5-filament, dynamics and disease.

Yoandris del Toro Duany¹, Bin Wu¹, Sun Hur².

Abstract

Melanoma Differentiation-Associated gene 5 (MDA5), encoded by the gene IFIH1, is a cytoplasmic sensor for viral double-stranded RNAs (dsRNAs). MDA5 activates the type I interferon signaling pathway upon detection of long viral dsRNA generated during replication of picornaviruses. Studies have shown that MDA5 forms a filament along the length of dsRNA and utilizes ATP-dependent filament dynamics to discriminate between self versus non-self on the basis of dsRNA length. This review summarizes our current understanding of how the MDA5 filament assembles and disassembles, how this filament dynamics are utilized in dsRNA length-dependent signaling, and how dysregulated filament dynamics lead to pathogenesis of immune disorders.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2015 PMID： 25676875 PMCID： PMC4470736 DOI： 10.1016/j.coviro.2015.01.011

Source DB: PubMed Journal: Curr Opin Virol ISSN： 1879-6257 Impact factor: 7.090

48 in total

1. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition.

Authors: Alys Peisley; Cecilie Lin; Bin Wu; McGhee Orme-Johnson; Mengyuan Liu; Thomas Walz; Sun Hur
Journal: Proc Natl Acad Sci U S A Date: 2011-12-12 Impact factor: 11.205

2. Structural basis of RNA recognition and activation by innate immune receptor RIG-I.

Authors: Fuguo Jiang; Anand Ramanathan; Matthew T Miller; Guo-Qing Tang; Michael Gale; Smita S Patel; Joseph Marcotrigiano
Journal: Nature Date: 2011-09-25 Impact factor: 49.962

3. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.

Authors: Eva Kowalinski; Thomas Lunardi; Andrew A McCarthy; Jade Louber; Joanna Brunel; Boyan Grigorov; Denis Gerlier; Stephen Cusack
Journal: Cell Date: 2011-10-14 Impact factor: 41.582

4. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.

Authors: Ian C Berke; Yorgo Modis
Journal: EMBO J Date: 2012-02-07 Impact factor: 11.598

5. Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.

Authors: Steve P Crampton; Jonathan A Deane; Lionel Feigenbaum; Silvia Bolland
Journal: J Immunol Date: 2011-12-28 Impact factor: 5.422

6. Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

Authors: Talin Robinson; Silvia N Kariuki; Beverly S Franek; Marissa Kumabe; Akaash A Kumar; Maria Badaracco; Rachel A Mikolaitis; Galen Guerrero; Tammy O Utset; Barbara E Drevlow; Laura S Zaacks; James S Grober; Lewis M Cohen; Kyriakos A Kirou; Mary K Crow; Meenakshi Jolly; Timothy B Niewold
Journal: J Immunol Date: 2011-06-24 Impact factor: 5.422

7. Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.

Authors: Xiaomo Jiang; Lisa N Kinch; Chad A Brautigam; Xiang Chen; Fenghe Du; Nick V Grishin; Zhijian J Chen
Journal: Immunity Date: 2012-06-14 Impact factor: 31.745

8. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

Authors: Fajian Hou; Lijun Sun; Hui Zheng; Brian Skaug; Qiu-Xing Jiang; Zhijian J Chen
Journal: Cell Date: 2011-07-21 Impact factor: 41.582

9. Structural insights into RNA recognition by RIG-I.

Authors: Dahai Luo; Steve C Ding; Adriana Vela; Andrew Kohlway; Brett D Lindenbach; Anna Marie Pyle
Journal: Cell Date: 2011-10-14 Impact factor: 41.582

10. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

Authors: Koji Onomoto; Michihiko Jogi; Ji-Seung Yoo; Ryo Narita; Shiho Morimoto; Azumi Takemura; Suryaprakash Sambhara; Atushi Kawaguchi; Suguru Osari; Kyosuke Nagata; Tomoh Matsumiya; Hideo Namiki; Mitsutoshi Yoneyama; Takashi Fujita
Journal: PLoS One Date: 2012-08-13 Impact factor: 3.240

24 in total

Review 1. The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA.

Authors: Jacki E Heraud-Farlow; Carl R Walkley
Journal: J Mol Med (Berl) Date: 2016-04-05 Impact factor: 4.599

Review 2. MDA5-Associated Neuroinflammation and the Singleton-Merten Syndrome: Two Faces of the Same Type I Interferonopathy Spectrum.

Authors: Insa Buers; Gillian I Rice; Yanick J Crow; Frank Rutsch
Journal: J Interferon Cytokine Res Date: 2017-05 Impact factor: 2.607

MDA5-filament, dynamics and disease.

1. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition.

2. Structural basis of RNA recognition and activation by innate immune receptor RIG-I.

3. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.

4. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.

5. Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.

6. Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.

7. Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.

8. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

9. Structural insights into RNA recognition by RIG-I.

10. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.

Review 1. The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA.

Review 2. MDA5-Associated Neuroinflammation and the Singleton-Merten Syndrome: Two Faces of the Same Type I Interferonopathy Spectrum.

Review 3. Filament assemblies in foreign nucleic acid sensors.

Review 4. Endogenous Retroelements and the Host Innate Immune Sensors.

5. Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation.

Review 6. Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.

Review 7. Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences.

8. Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC.

Review 9. Regulation of antiviral innate immune signaling by stress-induced RNA granules.

Review 10. MDA5-positive dermatomyositis: an uncommon entity in Europe with variable clinical presentations.