| Literature DB >> 25676373 |
Abstract
More than 9 million individuals donate blood annually in the United States. Between 200 and 250 mg of iron is removed with each whole blood donation, reflecting losses from the hemoglobin in red blood cells. Replenishment of iron stores takes many months, leading to a high rate of iron depletion. In an effort to better identify and prevent iron deficiency, blood collection centers are now considering various strategies to manage donor iron loss. This article highlights laboratory and genetic tests to assess the iron status of blood donors and their applicability as screening tests for blood donation.Entities:
Keywords: Blood donation; Ferritin; Hereditary hemochromatosis (HFE); Hypochromic mature red blood cells; Iron deficiency; Reticulocyte hemoglobin content; Soluble transferrin receptor; TMPRSS6
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Year: 2014 PMID: 25676373 PMCID: PMC4451195 DOI: 10.1016/j.cll.2014.10.011
Source DB: PubMed Journal: Clin Lab Med ISSN: 0272-2712 Impact factor: 1.935