Literature DB >> 25674248

Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes.

Wei-Ping Chen1, Li-Dong Wu1.   

Abstract

We investigated the anti-inflammatory properties of chlorogenic acid (CGA) in interleukin-1β-induced chondrocytes. The nitric oxide (NO) and prostaglandin E2 (PGE2) were detected by Griess and Enzyme-linked immunosorbent assay (ELISA) respectively. Quantitative real-time PCR and western blot were performed to measure the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. Our results indicate that CGA inhibited the production of NO and PGE2 as well as the expression of iNOS and COX-2 in chondrocytes. Our data suggest that CGA possess potential value in the treatment of OA.

Entities:  

Keywords:  Chlorogenic acid; chondrocyte; cyclooxygenase; inducible NO synthase

Mesh：

Substances：

Year:  2014        PMID： 25674248      PMCID： PMC4314010     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  15 in total

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