Literature DB >> 25673875

Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.

Byron C Knowles1, Victoria G Weis2, Shiyan Yu3, Joseph T Roland2, Janice A Williams4, Gabriela S Alvarado1, Lynne A Lapierre2, Mitchell D Shub5, Nan Gao6, James R Goldenring7.   

Abstract

Rab11a is a key component of the apical recycling endosome that aids in the trafficking of proteins to the luminal surface in polarized epithelial cells. Utilizing conditional Rab11a-knockout specific to intestinal epithelial cells, and human colonic epithelial CaCo2-BBE cells with stable Rab11a knockdown, we examined the molecular and pathological impact of Rab11a deficiency on the establishment of apical cell polarity and microvillus morphogenesis. We demonstrate that loss of Rab11a induced alterations in enterocyte polarity, shortened microvillar length and affected the formation of microvilli along the lateral membranes. Rab11a deficiency in enterocytes altered the apical localization of syntaxin 3. These data affirm the role of Rab11a in apical membrane trafficking and the maintenance of apical microvilli in enterocytes.
© 2015. Published by The Company of Biologists Ltd.

Entities:  

Keywords:  Enterocyte; Intestinal polarity; Microvilli; Rab11; Rab8; Syntaxin 3

Mesh：

Substances：

Year:  2015        PMID： 25673875      PMCID： PMC4518445          DOI： 10.1242/jcs.163303

Source DB:  PubMed          Journal:  J Cell Sci        ISSN： 0021-9533            Impact factor:   5.285


  35 in total

1.  A molecular network for de novo generation of the apical surface and lumen.

Authors:  David M Bryant; Anirban Datta; Alejo E Rodríguez-Fraticelli; Johan Peränen; Fernando Martín-Belmonte; Keith E Mostov
Journal:  Nat Cell Biol       Date:  2010-10-03       Impact factor: 28.824

2.  Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine.

Authors:  Robert L Jakab; Anne M Collaco; Nadia A Ameen
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-10-28       Impact factor: 4.052

3.  Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling.

Authors:  Lynne A Lapierre; Kenya M Avant; Catherine M Caldwell; Amy-Joan L Ham; Salisha Hill; Janice A Williams; Adam J Smolka; James R Goldenring
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2007-01-25       Impact factor: 4.052

4.  Rab11 regulates recycling through the pericentriolar recycling endosome.

Authors:  O Ullrich; S Reinsch; S Urbé; M Zerial; R G Parton
Journal:  J Cell Biol       Date:  1996-11       Impact factor: 10.539

5.  Loss of syntaxin 3 causes variant microvillus inclusion disease.

Authors:  Caroline L Wiegerinck; Andreas R Janecke; Kerstin Schneeberger; Georg F Vogel; Désirée Y van Haaften-Visser; Johanna C Escher; Rüdiger Adam; Cornelia E Thöni; Kristian Pfaller; Alexander J Jordan; Cleo-Aron Weis; Isaac J Nijman; Glen R Monroe; Peter M van Hasselt; Ernest Cutz; Judith Klumperman; Hans Clevers; Edward E S Nieuwenhuis; Roderick H J Houwen; Gijs van Haaften; Michael W Hess; Lukas A Huber; Janneke M Stapelbroek; Thomas Müller; Sabine Middendorp
Journal:  Gastroenterology       Date:  2014-04-12       Impact factor: 22.682

6.  Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.

Authors:  Byron C Knowles; Joseph T Roland; Moorthy Krishnan; Matthew J Tyska; Lynne A Lapierre; Paul S Dickman; James R Goldenring; Mitchell D Shub
Journal:  J Clin Invest       Date:  2014-06-02       Impact factor: 14.808

7.  Alternative splicing in class V myosins determines association with Rab10.

Authors:  Joseph T Roland; Lynne A Lapierre; James R Goldenring
Journal:  J Biol Chem       Date:  2008-11-12       Impact factor: 5.157

8.  Apical targeting of syntaxin 3 is essential for epithelial cell polarity.

Authors:  Nikunj Sharma; Seng Hui Low; Saurav Misra; Bhattaram Pallavi; Thomas Weimbs
Journal:  J Cell Biol       Date:  2006-06-19       Impact factor: 10.539

9.  Rab11a is required for apical protein localisation in the intestine.

Authors:  Tomoaki Sobajima; Shin-Ichiro Yoshimura; Tomohiko Iwano; Masataka Kunii; Masahiko Watanabe; Nur Atik; Sotaro Mushiake; Eiichi Morii; Yoshihisa Koyama; Eiji Miyoshi; Akihiro Harada
Journal:  Biol Open       Date:  2014-12-19       Impact factor: 2.422

10.  Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.

Authors:  Takashi Sato; Tomohiko Iwano; Masataka Kunii; Shinji Matsuda; Rumiko Mizuguchi; Yongwook Jung; Haruo Hagiwara; Yoshihiro Yoshihara; Michisuke Yuzaki; Reiko Harada; Akihiro Harada
Journal:  J Cell Sci       Date:  2013-11-08       Impact factor: 5.285
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  34 in total

Review 1.  Plasticity of the brush border - the yin and yang of intestinal homeostasis.

Authors:  Delphine Delacour; Julie Salomon; Sylvie Robine; Daniel Louvard
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2016-02-03       Impact factor: 46.802

2.  Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.

Authors:  Bhuminder Singh; Galina Bogatcheva; Alina Starchenko; Justine Sinnaeve; Lynne A Lapierre; Janice A Williams; James R Goldenring; Robert J Coffey
Journal:  J Cell Sci       Date:  2015-08-13       Impact factor: 5.285

3.  Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.

Authors:  Luca D'Agostino; Yingchao Nie; Sayantani Goswami; Kevin Tong; Shiyan Yu; Sheila Bandyopadhyay; Juan Flores; Xiao Zhang; Iyshwarya Balasubramanian; Ivor Joseph; Ryotaro Sakamori; Victoria Farrell; Qi Li; Chung S Yang; Bin Gao; Ronaldo P Ferraris; Ghassan Yehia; Edward M Bonder; James R Goldenring; Michael P Verzi; Lanjing Zhang; Y Tony Ip; Nan Gao
Journal:  Cancer Res       Date:  2019-06-25       Impact factor: 12.701

Review 4.  Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes.

Authors:  Amy Christine Engevik; James R Goldenring
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-01-02       Impact factor: 10.005

Review 5.  Rabs set the stage for polarity.

Authors:  Sara S Parker; Christopher Cox; Jean M Wilson
Journal:  Small GTPases       Date:  2017-01-27

Review 6.  RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.

Authors:  Xiao Zhang; Nan Gao
Journal:  Small GTPases       Date:  2016-05-04

7.  Crumbs organizes the transport machinery by regulating apical levels of PI(4,5)P2 in Drosophila.

Authors:  Johanna Lattner; Weihua Leng; Elisabeth Knust; Marko Brankatschk; David Flores-Benitez
Journal:  Elife       Date:  2019-11-07       Impact factor: 8.140

8.  An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.

Authors:  Kerstin Schneeberger; Georg F Vogel; Hans Teunissen; Domenique D van Ommen; Harry Begthel; Layla El Bouazzaoui; Anke H M van Vugt; Jeffrey M Beekman; Judith Klumperman; Thomas Müller; Andreas Janecke; Patrick Gerner; Lukas A Huber; Michael W Hess; Hans Clevers; Johan H van Es; Edward E S Nieuwenhuis; Sabine Middendorp
Journal:  Proc Natl Acad Sci U S A       Date:  2015-09-21       Impact factor: 11.205

9.  Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.

Authors:  Qiang Feng; Edward M Bonder; Amy C Engevik; Lanjing Zhang; Matthew J Tyska; James R Goldenring; Nan Gao
Journal:  J Cell Sci       Date:  2017-06-08       Impact factor: 5.285

Review 10.  Recycling endosomes.

Authors:  James R Goldenring
Journal:  Curr Opin Cell Biol       Date:  2015-05-27       Impact factor: 8.382
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