Literature DB >> 27142493

RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.

Xiao Zhang1, Nan Gao1.   

Abstract

Recent human and mouse genetic studies have highlighted important contributions of several small GTPases, in particular Rab8a, (1) Cdc42, (2-4) and Rab11a, (5-8) to the proper morphogenesis and function of the mature intestinal epithelia. Additional insights about the involvement of these factors in maintaining intestinal stem cell homeostasis have also been obtained. (9,10) These studies suggest a conserved vesicular and membrane trafficking program utilized by the gastrointestinal tissue to support the rapid epithelial cell turnover and the highly sophisticated physiology of mature epithelial cells.

Entities:  

Keywords:  CDC42; Microvillus Inclusion Disease; Paneth cell; RAB11; RAB8; Wnt secretion; enterocyte; intestinal stem cell; stem cell niche

Mesh：

Substances：

Year:  2016        PMID： 27142493      PMCID： PMC4905260          DOI： 10.1080/21541248.2016.1159274

Source DB:  PubMed          Journal:  Small GTPases        ISSN： 2154-1248


  45 in total

1.  RAB8B is required for activity and caveolar endocytosis of LRP6.

Authors:  Kubilay Demir; Nadine Kirsch; Carlo A Beretta; Gerrit Erdmann; Dierk Ingelfinger; Enrico Moro; Francesco Argenton; Matthias Carl; Christof Niehrs; Michael Boutros
Journal:  Cell Rep       Date:  2013-09-12       Impact factor: 9.423

Review 2.  Paneth cells: maestros of the small intestinal crypts.

Authors:  Hans C Clevers; Charles L Bevins
Journal:  Annu Rev Physiol       Date:  2013       Impact factor: 19.318

3.  Cdc42 interacts with the exocyst and regulates polarized secretion.

Authors:  X Zhang; E Bi; P Novick; L Du; K G Kozminski; J H Lipschutz; W Guo
Journal:  J Biol Chem       Date:  2001-10-10       Impact factor: 5.157

4.  Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK.

Authors:  Chirag Patel; Veronique Douard; Shiyan Yu; Phuntila Tharabenjasin; Nan Gao; Ronaldo P Ferraris
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-06-17       Impact factor: 3.619

5.  Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.

Authors:  Byron C Knowles; Joseph T Roland; Moorthy Krishnan; Matthew J Tyska; Lynne A Lapierre; Paul S Dickman; James R Goldenring; Mitchell D Shub
Journal:  J Clin Invest       Date:  2014-06-02       Impact factor: 14.808

6.  MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.

Authors:  Thomas Müller; Michael W Hess; Natalia Schiefermeier; Kristian Pfaller; Hannes L Ebner; Peter Heinz-Erian; Hannes Ponstingl; Joachim Partsch; Barbara Röllinghoff; Henrik Köhler; Thomas Berger; Henning Lenhartz; Barbara Schlenck; Roderick J Houwen; Christopher J Taylor; Heinz Zoller; Silvia Lechner; Olivier Goulet; Gerd Utermann; Frank M Ruemmele; Lukas A Huber; Andreas R Janecke
Journal:  Nat Genet       Date:  2008-08-24       Impact factor: 38.330

7.  Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).

Authors:  Aurélie Durand; Bridgitte Donahue; Grégory Peignon; Franck Letourneur; Nicolas Cagnard; Christian Slomianny; Christine Perret; Noah F Shroyer; Béatrice Romagnolo
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-14       Impact factor: 11.205

8.  Rab11a is required for apical protein localisation in the intestine.

Authors:  Tomoaki Sobajima; Shin-Ichiro Yoshimura; Tomohiko Iwano; Masataka Kunii; Masahiko Watanabe; Nur Atik; Sotaro Mushiake; Eiichi Morii; Yoshihisa Koyama; Eiji Miyoshi; Akihiro Harada
Journal:  Biol Open       Date:  2014-12-19       Impact factor: 2.422

9.  TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.

Authors:  Shiyan Yu; Yingchao Nie; Byron Knowles; Ryotaro Sakamori; Ewa Stypulkowski; Chirag Patel; Soumyashree Das; Veronique Douard; Ronaldo P Ferraris; Edward M Bonder; James R Goldenring; Yicktung Tony Ip; Nan Gao
Journal:  EMBO J       Date:  2014-07-24       Impact factor: 11.598

10.  Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane.

Authors:  L A Huber; S Pimplikar; R G Parton; H Virta; M Zerial; K Simons
Journal:  J Cell Biol       Date:  1993-10       Impact factor: 10.539
View more
  8 in total

1.  Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.

Authors:  Luca D'Agostino; Yingchao Nie; Sayantani Goswami; Kevin Tong; Shiyan Yu; Sheila Bandyopadhyay; Juan Flores; Xiao Zhang; Iyshwarya Balasubramanian; Ivor Joseph; Ryotaro Sakamori; Victoria Farrell; Qi Li; Chung S Yang; Bin Gao; Ronaldo P Ferraris; Ghassan Yehia; Edward M Bonder; James R Goldenring; Michael P Verzi; Lanjing Zhang; Y Tony Ip; Nan Gao
Journal:  Cancer Res       Date:  2019-06-25       Impact factor: 12.701

2.  Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila.

Authors:  Yingchao Nie; Shiyan Yu; Qi Li; Niraj K Nirala; Alla Amcheslavsky; Yvonne J K Edwards; Patrick W Shum; Zhong Jiang; Wei Wang; Biliang Zhang; Nan Gao; Y Tony Ip
Journal:  Genetics       Date:  2019-06-18       Impact factor: 4.562

3.  Intestinal GPCRs Control Paneth Cell Maturation and Susceptibility to Experimental Colitis.

Authors:  Xiao Zhang; Nan Gao
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2016-09-24

Review 4.  Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease.

Authors:  Azzurra Margiotta; Cecilia Bucci
Journal:  Cells       Date:  2019-04-29       Impact factor: 6.600

Review 5.  The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases.

Authors:  Younggeon Jin; Anthony T Blikslager
Journal:  Int J Mol Sci       Date:  2020-05-18       Impact factor: 5.923

6.  Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration.

Authors:  Xiao Zhang; Sheila Bandyopadhyay; Leandro Pires Araujo; Kevin Tong; Juan Flores; Daniel Laubitz; Yanlin Zhao; George Yap; Jingren Wang; Qingze Zou; Ronaldo Ferraris; Lanjing Zhang; Wenwei Hu; Edward M Bonder; Pawel R Kiela; Robert Coffey; Michael P Verzi; Ivaylo I Ivanov; Nan Gao
Journal:  JCI Insight       Date:  2020-08-20

7.  Formation of Giant Lysosome in Neonatal Ileal Enterocytes Requires Endotubin.

Authors:  Xiao Zhang; Nan Gao
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2017-11-27

8.  Terminal web and vesicle trafficking proteins mediate nematode single-cell tubulogenesis.

Authors:  Zhe Yang; Brendan C Mattingly; David H Hall; Brian D Ackley; Matthew Buechner
Journal:  J Cell Biol       Date:  2020-11-02       Impact factor: 10.539
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.