Kate Smolina1, Clare J Wotton, Michael J Goldacre. 1. Centre for Health Services and Policy Research, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Abstract
AIMS/HYPOTHESIS: Type 2 diabetes increases the risk of subsequent dementia. Our objective was to determine whether a similar risk of subsequent dementia is associated with type 1 diabetes in a large defined population. METHODS: This retrospective cohort study examined national administrative record-linked statistical data on hospital care and mortality in England, 1998-2011. Cohorts of people admitted to hospital when aged 30 or over were constructed: 343,062 people with type 1 diabetes; 1,855,141 people with type 2 diabetes; and a reference cohort. Results were expressed as rate ratios (RR) comparing each diabetes cohort with the control cohort. RESULTS: The overall RR for dementia in people admitted to hospital with type 1 diabetes was 1.65 (95% CI 1.61, 1.68), and for people admitted to hospital with type 2 diabetes was 1.37 (1.35, 1.38). Young age at admission for diabetes appeared to confer a greater rate of subsequent dementia; the RR for dementia in people admitted to hospital with type 1 diabetes aged 30-39 years was 7.10 (4.65, 10.6), which reduced to 4.40 (3.55, 5.40) in those aged 40-49 at admission, and further reduced with increasing age to 1.16 (1.11, 1.20) in those aged 80 or over at admission. A similar pattern was seen with type 2 diabetes. CONCLUSIONS/ INTERPRETATION: Type 1 diabetes, as well as type 2 diabetes, may be associated with an elevated risk of subsequent dementia. The risk of dementia varies with age at admission to hospital with diabetes, and appears to be much greater in the young.
AIMS/HYPOTHESIS: Type 2 diabetes increases the risk of subsequent dementia. Our objective was to determine whether a similar risk of subsequent dementia is associated with type 1 diabetes in a large defined population. METHODS: This retrospective cohort study examined national administrative record-linked statistical data on hospital care and mortality in England, 1998-2011. Cohorts of people admitted to hospital when aged 30 or over were constructed: 343,062 people with type 1 diabetes; 1,855,141 people with type 2 diabetes; and a reference cohort. Results were expressed as rate ratios (RR) comparing each diabetes cohort with the control cohort. RESULTS: The overall RR for dementia in people admitted to hospital with type 1 diabetes was 1.65 (95% CI 1.61, 1.68), and for people admitted to hospital with type 2 diabetes was 1.37 (1.35, 1.38). Young age at admission for diabetes appeared to confer a greater rate of subsequent dementia; the RR for dementia in people admitted to hospital with type 1 diabetes aged 30-39 years was 7.10 (4.65, 10.6), which reduced to 4.40 (3.55, 5.40) in those aged 40-49 at admission, and further reduced with increasing age to 1.16 (1.11, 1.20) in those aged 80 or over at admission. A similar pattern was seen with type 2 diabetes. CONCLUSIONS/ INTERPRETATION:Type 1 diabetes, as well as type 2 diabetes, may be associated with an elevated risk of subsequent dementia. The risk of dementia varies with age at admission to hospital with diabetes, and appears to be much greater in the young.
Authors: C C Patterson; E Gyürüs; J Rosenbauer; O Cinek; A Neu; E Schober; R C Parslow; G Joner; J Svensson; C Castell; P J Bingley; E Schoenle; P Jarosz-Chobot; B Urbonaité; U Rothe; C Krzisnik; C Ionescu-Tirgoviste; I Weets; M Kocova; G Stipancic; M Samardzic; C E de Beaufort; A Green; G G Dahlquist; G Soltész Journal: Diabetologia Date: 2012-05-26 Impact factor: 10.122
Authors: Augustina M A Brands; Geert Jan Biessels; Edward H F de Haan; L Jaap Kappelle; Roy P C Kessels Journal: Diabetes Care Date: 2005-03 Impact factor: 19.112
Authors: Kendra Vehik; Richard F Hamman; Dennis Lezotte; Jill M Norris; Georgeanna Klingensmith; Clifford Bloch; Marian Rewers; Dana Dabelea Journal: Diabetes Care Date: 2007-03 Impact factor: 19.112
Authors: Eelco van Duinkerken; Menno M Schoonheim; Richard G IJzerman; Annette C Moll; Jesus Landeira-Fernandez; Martin Klein; Michaela Diamant; Frank J Snoek; Frederik Barkhof; Alle-Meije Wink Journal: Hum Brain Mapp Date: 2017-04-21 Impact factor: 5.038
Authors: Garrett Strizich; Robert C Kaplan; Hector M González; Martha L Daviglus; Aida L Giachello; Yanping Teng; Richard B Lipton; Ellen Grober Journal: Diabetes Res Clin Pract Date: 2016-05-06 Impact factor: 5.602
Authors: Liora G Rodill; Lieza G Exalto; Paola Gilsanz; Geert Jan Biessels; Charles P Quesenberry; Rachel A Whitmer Journal: Alzheimer Dis Assoc Disord Date: 2018 Apr-Jun Impact factor: 2.703
Authors: Eelco van Duinkerken; Richard G Ijzerman; Martin Klein; Annette C Moll; Frank J Snoek; Philip Scheltens; Petra J W Pouwels; Frederik Barkhof; Michaela Diamant; Betty M Tijms Journal: Hum Brain Mapp Date: 2015-12-23 Impact factor: 5.038
Authors: Paola Gilsanz; Michal Schnaider Beeri; Andrew J Karter; Charles P Quesenberry; Alyce S Adams; Rachel A Whitmer Journal: Aging Ment Health Date: 2018-04-10 Impact factor: 3.658
Authors: Gail Musen; Liane J Tinsley; Katrina A Marcinkowski; David Pober; Jennifer K Sun; Maya Khatri; Richie Huynh; Annie Lu; George L King; Hillary A Keenan Journal: Diabetes Care Date: 2018-06-05 Impact factor: 19.112