AIMS/HYPOTHESIS: The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period. METHODS: All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture-recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied. RESULTS: Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half. CONCLUSIONS/ INTERPRETATION: The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3-4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted.
AIMS/HYPOTHESIS: The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period. METHODS: All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture-recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied. RESULTS: Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half. CONCLUSIONS/ INTERPRETATION: The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3-4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted.
Authors: Dana Dabelea; Arleta Rewers; Jeanette M Stafford; Debra A Standiford; Jean M Lawrence; Sharon Saydah; Giuseppina Imperatore; Ralph B D'Agostino; Elizabeth J Mayer-Davis; Catherine Pihoker Journal: Pediatrics Date: 2014-03-31 Impact factor: 7.124
Authors: Elizabeth J Mayer-Davis; Jean M Lawrence; Dana Dabelea; Jasmin Divers; Scott Isom; Lawrence Dolan; Giuseppina Imperatore; Barbara Linder; Santica Marcovina; David J Pettitt; Catherine Pihoker; Sharon Saydah; Lynne Wagenknecht Journal: N Engl J Med Date: 2017-04-13 Impact factor: 91.245
Authors: Steffen U Thorsen; Karl Mårild; Sjurdur F Olsen; Klaus K Holst; German Tapia; Charlotta Granström; Thorhallur I Halldorsson; Arieh S Cohen; Margaretha Haugen; Marika Lundqvist; Torild Skrivarhaug; Pål R Njølstad; Geir Joner; Per Magnus; Ketil Størdal; Jannet Svensson; Lars C Stene Journal: Am J Epidemiol Date: 2018-06-01 Impact factor: 4.897
Authors: Juan Huang; James A Pearson; Jian Peng; Youjia Hu; Sha Sha; Yanpeng Xing; Gan Huang; Xia Li; Fang Hu; Zhiguo Xie; Yang Xiao; Shuoming Luo; Chen Chao; F Susan Wong; Zhiguang Zhou; Li Wen Journal: JCI Insight Date: 2020-05-21
Authors: Christopher C Patterson; Valma Harjutsalo; Joachim Rosenbauer; Andreas Neu; Ondrej Cinek; Torild Skrivarhaug; Birgit Rami-Merhar; Gyula Soltesz; Jannet Svensson; Roger C Parslow; Conxa Castell; Eugen J Schoenle; Polly J Bingley; Gisela Dahlquist; Przemysława K Jarosz-Chobot; Dalė Marčiulionytė; Edna F Roche; Ulrike Rothe; Natasa Bratina; Constantin Ionescu-Tirgoviste; Ilse Weets; Mirjana Kocova; Valentino Cherubini; Natasa Rojnic Putarek; Carine E deBeaufort; Mira Samardzic; Anders Green Journal: Diabetologia Date: 2018-11-28 Impact factor: 10.122