| Literature DB >> 25670078 |
David P Kodack1, Vasileios Askoxylakis1, Gino B Ferraro1, Dai Fukumura1, Rakesh K Jain2.
Abstract
Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of months. The incidence of brain metastatic disease is increasing with the improved management of systemic disease and prolongation of survival. Unfortunately, the targeted therapies that control systemic disease have diminished efficacy against brain lesions. There are reasons to be optimistic, however, as emerging therapies have shown promise in preclinical and early clinical settings. This review discusses recent advances in breast cancer brain metastasis therapy and potential approaches for successful treatment.Entities:
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Year: 2015 PMID： 25670078 PMCID： PMC4325273 DOI： 10.1016/j.ccell.2015.01.001
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743