Sedigheh Miranzadeh1, Mohsen Adib-Hajbaghery2, Leyla Soleymanpoor1, Majid Ehsani3. 1. Department of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran. 2. Department of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: adib1344@yahoo.com. 3. Department of Internal Medicine, Shahid Beheshti Medical Center, Kashan University of Medical Sciences, Kashan, Iran.
Abstract
BACKGROUND:Oral mucositis (OM) is a debilitating side-effect of chemotherapy. It has different complications, including impairment of drinking, eating and even talking, sometimes so severe that physician stops the therapy. OBJECTIVE: Investigating the effect of Achillea millefolium distillate solution in the treatment of chemotherapy-induced OM. INTERVENTIONS/ METHODS: In this randomized controlled trial, 56 cancer patients with chemotherapy-induced OM were randomly assigned into control and experimental groups in similar blocks based on the severity of OM. The experimental group gargled 15 mL of a mixture of routine solution and distilled A. millefolium 4 times a day for 14 days while the control group gargled 15 mL of routine solution. The severity of OM was assessed at three times before, 7 and 14 days after intervention. Data was analyzed using Wilcoxon, Kruskal-Wallis, Mann-Whitney U, Friedman, Chi-square and Fisher's exact tests. RESULTS: The mean severity score of OM was 2.39 ± 0.875 in both groups at start of the study that was changed to 1.07 ± 0.85 and 0.32 ± 0.54 in the intervention group in days 7 and 14 (p < 0.001). However, the severity of OM was increased to 2.75 ± 0.87 and 2.89 ± 0.956 in the control group respectively (p < 0.001). CONCLUSIONS: A. millefolium distillate healed OM much more than the routine solution. Therefore, it is suggested to be used in patients with chemotherapy-induced OM. The study was registered in the Iranian Registry of Clinical Trials, Number: IRCT2013092214729N1.
RCT Entities:
BACKGROUND:Oral mucositis (OM) is a debilitating side-effect of chemotherapy. It has different complications, including impairment of drinking, eating and even talking, sometimes so severe that physician stops the therapy. OBJECTIVE: Investigating the effect of Achillea millefolium distillate solution in the treatment of chemotherapy-induced OM. INTERVENTIONS/ METHODS: In this randomized controlled trial, 56 cancerpatients with chemotherapy-induced OM were randomly assigned into control and experimental groups in similar blocks based on the severity of OM. The experimental group gargled 15 mL of a mixture of routine solution and distilled A. millefolium 4 times a day for 14 days while the control group gargled 15 mL of routine solution. The severity of OM was assessed at three times before, 7 and 14 days after intervention. Data was analyzed using Wilcoxon, Kruskal-Wallis, Mann-Whitney U, Friedman, Chi-square and Fisher's exact tests. RESULTS: The mean severity score of OM was 2.39 ± 0.875 in both groups at start of the study that was changed to 1.07 ± 0.85 and 0.32 ± 0.54 in the intervention group in days 7 and 14 (p < 0.001). However, the severity of OM was increased to 2.75 ± 0.87 and 2.89 ± 0.956 in the control group respectively (p < 0.001). CONCLUSIONS:A. millefolium distillate healed OM much more than the routine solution. Therefore, it is suggested to be used in patients with chemotherapy-induced OM. The study was registered in the Iranian Registry of Clinical Trials, Number: IRCT2013092214729N1.
Authors: Ana Sofia Ferreira; Catarina Macedo; Ana Margarida Silva; Cristina Delerue-Matos; Paulo Costa; Francisca Rodrigues Journal: Int J Mol Sci Date: 2022-04-15 Impact factor: 6.208
Authors: Patrícia Leão Castillo Eubank; Lucas Guimaraes Abreu; Ivana Povoa Violante; Luiz Evaristo Ricci Volpato Journal: Support Care Cancer Date: 2021-05-14 Impact factor: 3.603
Authors: Geisa Sant Ana; Ana Gabriela Costa Normando; Isabela De Toledo; Paula Elaine Diniz Dos Reis; Eliete Neves Silva Guerra Journal: Asian Pac J Cancer Prev Date: 2020-07-01
Authors: Pirus Ghadjar; Wiebke Stritter; Irina von Mackensen; Felix Mehrhof; Clara Foucré; Vincent H Ehrhardt; Marcus Beck; Pimrapat Gebert; Goda Kalinauskaite; Jacqueline S Luchte; Carmen Stromberger; Volker Budach; Angelika Eggert; Georg Seifert Journal: Radiat Oncol Date: 2021-04-19 Impact factor: 3.481