PURPOSE: This systematic review aimed to identify effective medicinal plants for the treatment of mucositis induced by oncotherapy. METHODS: The clinical question was the following: "Which medicinal plants are effective in the treatment of oral mucositis induced by cancer treatment?" (PubMed, Medline, Web of Science, Scopus, Lilacs, and SciELO). The keywords were the following: phytotherapy OR "herbal drug" OR "plant extract" OR plant OR "medicinal plant" OR pharmacognosy OR ethnobotany OR ethnomedicine OR ethnopharmacology OR "flower essences" OR "natural product" AND mucositis OR mucositides OR stomatitis OR stomatitides OR "oral ulcer" AND chemotherapy OR radiotherapy OR immunotherapy OR cancer OR neoplasm OR neoplasm OR tumor OR tumor. The inclusion criteria for the selection of articles were the type of study design (clinical trials) and the studied population (cancer patients presenting lesions of oral mucositis having undergone treatment with medicinal plants). RESULTS: After evaluation of the works, 24 of 893 articles were selected. Matricaria chamomilla (chamomilla) presented promising results, such as a reduction in severity and lesion incidence with improved pain symptomatology. The plant extracts Isatis indigótica, Olea europaea, Calendula officinalis, A. digitatae, and M. sylvestris improved the lesions. Mucotrol™ and QRLYD herbal products improved the degree of severity of the lesions, while SAMITAL® and MUCOSYTE allowed for greater pain control. CONCLUSION: The complementary treatment of oral mucositis in cancer patients, with analgesic and anti-inflammatory actions with lower side effects, is an alternative for healthcare professionals.
PURPOSE: This systematic review aimed to identify effective medicinal plants for the treatment of mucositis induced by oncotherapy. METHODS: The clinical question was the following: "Which medicinal plants are effective in the treatment of oral mucositis induced by cancer treatment?" (PubMed, Medline, Web of Science, Scopus, Lilacs, and SciELO). The keywords were the following: phytotherapy OR "herbal drug" OR "plant extract" OR plant OR "medicinal plant" OR pharmacognosy OR ethnobotany OR ethnomedicine OR ethnopharmacology OR "flower essences" OR "natural product" AND mucositis OR mucositides OR stomatitis OR stomatitides OR "oral ulcer" AND chemotherapy OR radiotherapy OR immunotherapy OR cancer OR neoplasm OR neoplasm OR tumor OR tumor. The inclusion criteria for the selection of articles were the type of study design (clinical trials) and the studied population (cancer patients presenting lesions of oral mucositis having undergone treatment with medicinal plants). RESULTS: After evaluation of the works, 24 of 893 articles were selected. Matricaria chamomilla (chamomilla) presented promising results, such as a reduction in severity and lesion incidence with improved pain symptomatology. The plant extracts Isatis indigótica, Olea europaea, Calendula officinalis, A. digitatae, and M. sylvestris improved the lesions. Mucotrol™ and QRLYD herbal products improved the degree of severity of the lesions, while SAMITAL® and MUCOSYTE allowed for greater pain control. CONCLUSION: The complementary treatment of oral mucositis in cancer patients, with analgesic and anti-inflammatory actions with lower side effects, is an alternative for healthcare professionals.
Authors: A Rodríguez-Caballero; D Torres-Lagares; M Robles-García; J Pachón-Ibáñez; D González-Padilla; J L Gutiérrez-Pérez Journal: Int J Oral Maxillofac Surg Date: 2011-11-08 Impact factor: 2.789
Authors: André Luiz Peixoto Figueiredo; Liliane Lins; Ana Carolina Cattony; Antônio Fernando Pereira Falcão Journal: Rev Assoc Med Bras (1992) Date: 2013-10-10 Impact factor: 1.209
Authors: Denise R P Vieira; Flavia MaM Amaral; Márcia C G Maciel; Flávia R F Nascimento; Silvana A Libério; Vandílson P Rodrigues Journal: J Ethnopharmacol Date: 2014-07-18 Impact factor: 4.360
Authors: P Fidler; C L Loprinzi; J R O'Fallon; J M Leitch; J K Lee; D L Hayes; P Novotny; D Clemens-Schutjer; J Bartel; J C Michalak Journal: Cancer Date: 1996-02-01 Impact factor: 6.860
Authors: Ingeborg Klymiuk; Ceren Bilgilier; Alexander Mahnert; Andreas Prokesch; Christoph Heininger; Ingeborg Brandl; Hanka Sahbegovic; Christian Singer; Thorsten Fuereder; Christoph Steininger Journal: Front Oncol Date: 2022-08-09 Impact factor: 5.738