| Literature DB >> 25666819 |
Megan K Thorson1, Ryan M Van Wagoner1, Mary Kay Harper1, Chris M Ireland1, Tomas Majtan2, Jan P Kraus2, Amy M Barrios3.
Abstract
A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H2S) by cystathionine beta-synthase (CBS). Eight hits were validated and shown to inhibit CBS activity with IC50 values ranging from 83 to 187μM. The majority of hits came from a series of synthetic polyandrocarpamine derivatives. In addition, a modified fluorogenic probe for H2S detection with improved solubility in aqueous solutions is reported.Entities:
Keywords: Fluorogenic probe; Hydrogen sulfide; Inhibitor screen; Sulfur metabolism
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Year: 2015 PMID： 25666819 DOI： 10.1016/j.bmcl.2015.01.013
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823