Afshin Mohammadi1, Kamran Shateri2, Farhad Behzadi1, Tooraj Maleki-Miandoab1, Emal Lesha3, Mohammad Ghasemi-Rad4, Yousef Rosta2. 1. Department of Radiology, Solid Tumor Research Center, Urmia University of Medical Sciences Urmia 5716763111, Iran. 2. Department of Gastroenterology, Imam Khomaini Hospital, Urmia University of Medical Sciences Urmia 5716763111, Iran. 3. College of Science and Mathematics, University of Massachusetts Boston Boston, MA 02125, United States ; Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Cambridge, MA 02139, United States. 4. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Cambridge, MA 02139, United States ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Cambridge, MA 02139, United States.
Abstract
BACKGROUND: Osteoporosis and atherosclerosis are two conditions that confer the major cause of mortality and morbidity in postmenopausal women. Several studies have suggested that these two conditions are negatively correlated by a common pathway. The aim of our study was to show a relationship between bone mineral density (BMD) and carotid intima media thickness (CIMT), as two factors that are directly related to osteoporosis and atherosclerosis respectively. METHODS: The study group consisted of 136 postmenopausal women that presented at the Radiology Clinic of our hospital for BMD measurements. The CIMT was measured using High Resolution B mode Ultrasonography; BMD was measured at the lumbar spine and femoral neck using Dual-energy X-Ray Absorptiometry. RESULTS: The mean IMT value in osteoporotic women (0.7±0.1 mm) was significantly higher compared to non-osteoporotic women (0.6±0.1 mm, P < 0.001). A significant negative correlation was found between CIMT and the T score of lumbar spine (r=-0.35; P < 0.001) and femoral neck (r=-0.23, P < 0.001), as well as Z score of the lumbar spine (r=-0.27, P=0.004). No significant correlation was found between CIMT and Z score of the femoral neck. CONCLUSION: Our study shows that bone mineral density and carotid intima media thickness are negatively correlated, thus showing a possible relationship between osteoporosis and atherosclerosis. However, more research is necessary to determine the pathway that connects these two conditions.
BACKGROUND:Osteoporosis and atherosclerosis are two conditions that confer the major cause of mortality and morbidity in postmenopausal women. Several studies have suggested that these two conditions are negatively correlated by a common pathway. The aim of our study was to show a relationship between bone mineral density (BMD) and carotid intima media thickness (CIMT), as two factors that are directly related to osteoporosis and atherosclerosis respectively. METHODS: The study group consisted of 136 postmenopausal women that presented at the Radiology Clinic of our hospital for BMD measurements. The CIMT was measured using High Resolution B mode Ultrasonography; BMD was measured at the lumbar spine and femoral neck using Dual-energy X-Ray Absorptiometry. RESULTS: The mean IMT value in osteoporoticwomen (0.7±0.1 mm) was significantly higher compared to non-osteoporoticwomen (0.6±0.1 mm, P < 0.001). A significant negative correlation was found between CIMT and the T score of lumbar spine (r=-0.35; P < 0.001) and femoral neck (r=-0.23, P < 0.001), as well as Z score of the lumbar spine (r=-0.27, P=0.004). No significant correlation was found between CIMT and Z score of the femoral neck. CONCLUSION: Our study shows that bone mineral density and carotid intima media thickness are negatively correlated, thus showing a possible relationship between osteoporosis and atherosclerosis. However, more research is necessary to determine the pathway that connects these two conditions.
Entities:
Keywords:
Bone mineral density; carotid intima media thickness; osteoporosis; postmenopausal women
Authors: Tina Trdan Lušin; Aleš Mrhar; Janja Marc; Jurij Trontelj; Andrej Zavratnik; Branka Zegura; Marija Pfeifer; Barbara Ostanek Journal: Wien Klin Wochenschr Date: 2014-05-20 Impact factor: 1.704
Authors: László B Tankó; Claus Christiansen; David A Cox; Mary Jane Geiger; Michelle A McNabb; Steven R Cummings Journal: J Bone Miner Res Date: 2005-07-18 Impact factor: 6.741
Authors: Junichiro Takasu; Matthew J Budoff; Ronit Katz; Juan J Rivera; Kevin D O'Brien; David M Shavelle; Jeffrey L Probstfield; Daniel O'Leary; Khurram Nasir Journal: Atherosclerosis Date: 2009-09-15 Impact factor: 5.162
Authors: M Bauer; B Hoffmann; S Möhlenkamp; N Lehmann; S Moebus; U Roggenbuck; C Berg; H Kälsch; A A Mahabadi; K Kara; K-H Jöckel; R Erbel Journal: Herz Date: 2012-11-25 Impact factor: 1.443