Literature DB >> 25663997

Anti-allodynia effect of safranal on neuropathic pain induced by spinal nerve transection in rat.

Ke-Jun Zhu1, Ji-Shun Yang1.   

Abstract

In this study, we investigated the anti-allodynia effect of safranal, the main volatile constitute of saffron, in spinal nerve transection model of rats. Meanwhile, to elucidate the mechanism, we determined the dynamic expression changes of glial activation markers (GFAP and OX-42) and inflammatory cytokines (TNF-α and IL-1β) in ipsilateral dorsal horn of lumbar enlargement post surgery. Results showed significant increase of these markers along with development of mechanical allodynia. Safranal (0.1 mg/kg, i.p.) attenuated the pain sensitivity and inhibited the expression of these markers. The results demonstrate that the antiallodynia effect of safranal after nerve injury might be attributed to its inhibiting effect on glial activation and inflammatory cytokine production in central nervous system.

Entities:  

Keywords:  Safranal; anti-allodynia; glial activation; pro-inflammatory cytokines; spinal nerve transection

Year:  2014        PMID： 25663997      PMCID： PMC4307444     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  26 in total

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4.  Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats.

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  6 in total

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5.  TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal.

Authors:  Simone Li Puma; Lorenzo Landini; Sergio J Macedo; Viola Seravalli; Ilaria M Marone; Elisabetta Coppi; Riccardo Patacchini; Pierangelo Geppetti; Serena Materazzi; Romina Nassini; Francesco De Logu
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6.  Safranal-promoted differentiation and survival of dopaminergic neurons in an animal model of Parkinson's disease.

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