| Literature DB >> 25658535 |
S Qiu1, X Xu2, C Yang1, J Wang1, B Liang3, P Li1, H Li1, S Yi1, H Liu1, X Cui1, Z Wu1, J Xie1, L Jia1, L Wang1, R Hao1, H Jin2, Y Wang1, Y Sun1, H Song4.
Abstract
We identified 2912 Shigella isolates from diarrhoeal patients in China during 2003-2013. The most common species was Shigella flexneri (55.3%), followed by Shigella sonnei (44.1%); however, S. sonnei is becoming increasingly prevalent. Among the S. flexneri isolates, serotypes 2a and X variant (-:7,8, E1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. Overall, S. sonnei, S. flexneri 2a and S. flexneri X variant (-:7,8, E1037) accounted for 76.1% of all Shigella isolates, and their prevalence increased from 54.0% during 2003-2004 to 84.1% during 2011-2013. A change was observed in the serotype distribution of Shigella in China during this period, and we propose an ideal strategy to inform the development of a broadly effective Shigella vaccine candidate.Entities:
Keywords: Atypical serotype; Shigella; serotype distribution; shift; vaccine development
Mesh：
Year: 2014 PMID： 25658535 DOI： 10.1016/j.cmi.2014.10.019
Source DB: PubMed Journal: Clin Microbiol Infect ISSN： 1198-743X Impact factor: 8.067