Literature DB >> 25658366

Do mutational dynamics in stem cells explain the origin of common cancers?

Gerry P Crossan1, Juan I Garaycoechea2, Ketan J Patel3.   

Abstract

For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25658366     DOI： 10.1016/j.stem.2015.01.009

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  3 in total

1.  Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.

Authors:  Cristian Tomasetti; Justin Poling; Nicholas J Roberts; Nyall R London; Meredith E Pittman; Michael C Haffner; Anthony Rizzo; Alex Baras; Baktiar Karim; Antonio Kim; Christopher M Heaphy; Alan K Meeker; Ralph H Hruban; Christine A Iacobuzio-Donahue; Bert Vogelstein
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-23       Impact factor: 11.205

Review 2.  Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy.

Authors:  Jeffrey L Platt; Xiaofeng Zhou; Adam R Lefferts; Marilia Cascalho
Journal:  Int J Mol Sci       Date:  2016-07-13       Impact factor: 5.923

3.  Mutational signature distribution varies with DNA replication timing and strand asymmetry.

Authors:  Marketa Tomkova; Jakub Tomek; Skirmantas Kriaucionis; Benjamin Schuster-Böckler
Journal:  Genome Biol       Date:  2018-09-10       Impact factor: 13.583
  3 in total

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