Cheng-Ta Li1, Tung-Ping Su1, Shyh-Jen Wang1, Pei-Chi Tu1, Jen-Chuen Hsieh1. 1. Cheng-Ta Li, MD, PhD, Tung-Ping Su, MD, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Institute of Brain Science, and Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei; Shyh-Jen Wang, MD, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei; Pei-Chi Tu, MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, and Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei; Jen-Chuen Hsieh, MD, PhD, Institute of Brain Science, National Yang-Ming University, Taipei, Integrated Brain Research Unit, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, and Centre of Neuropsychiatric Research, National Health and Research Institute, ChuNan, Taiwan.
Abstract
BACKGROUND: Medication-resistant depression (MRD) is associated with poorer attentional performance and immense socioeconomic costs. AIMS: We aimed to investigate the central pathophysiology of MRD, previously linked to impaired prefrontal cortex function. METHOD: A total of 54 participants (22 with MRD, 16 with non-resistant depression, 16 healthy controls) were recruited. Non-MRD status was confirmed by a prospective 6-week antidepressant trial. All medication-free participants underwent a go/no-go task to study prefrontal cortical function (attention) and positron emission tomography scans to study regional cerebral glucose metabolism (rCMglu) at rest. RESULTS: The MRD group had worse attentional ratings and decreased rCMglu compared with the non-MRD and control groups. Attentional performance was positively associated with prefrontal cortex rCMglu. The prefrontal cortex differences between MRD and non-MRD groups remained after adjusting for past depressive episodes (F(1,35) = 4.154, P = 0.043). CONCLUSIONS: Pronounced hypofrontality, with the associated attentional deficits, has a key role in the neuropathology of medication-resistant depression. Royal College of Psychiatrists.
BACKGROUND: Medication-resistant depression (MRD) is associated with poorer attentional performance and immense socioeconomic costs. AIMS: We aimed to investigate the central pathophysiology of MRD, previously linked to impaired prefrontal cortex function. METHOD: A total of 54 participants (22 with MRD, 16 with non-resistant depression, 16 healthy controls) were recruited. Non-MRD status was confirmed by a prospective 6-week antidepressant trial. All medication-free participants underwent a go/no-go task to study prefrontal cortical function (attention) and positron emission tomography scans to study regional cerebral glucose metabolism (rCMglu) at rest. RESULTS: The MRD group had worse attentional ratings and decreased rCMglu compared with the non-MRD and control groups. Attentional performance was positively associated with prefrontal cortex rCMglu. The prefrontal cortex differences between MRD and non-MRD groups remained after adjusting for past depressive episodes (F(1,35) = 4.154, P = 0.043). CONCLUSIONS: Pronounced hypofrontality, with the associated attentional deficits, has a key role in the neuropathology of medication-resistant depression. Royal College of Psychiatrists.
Authors: José V Pardo; Sohail A Sheikh; Graeme Schwindt; Joel T Lee; David E Adson; Barry Rittberg; Faruk S Abuzzahab Journal: PLoS One Date: 2020-01-13 Impact factor: 3.240
Authors: Ashish K Sahib; Joana Ra Loureiro; Megha M Vasavada; Antoni Kubicki; Benjamin Wade; Shantanu H Joshi; Roger P Woods; Eliza Congdon; Randall Espinoza; Katherine L Narr Journal: Transl Psychiatry Date: 2020-07-30 Impact factor: 7.989