Literature DB >> 25656896

Blockade of specific NOTCH ligands: a new promising approach in cancer therapy.

Anaïs Briot1, M Luisa Iruela-Arispe2.   

Abstract

SUMMARY: The signaling specificity conveyed by distinct combination of NOTCH receptors/ligands has remained elusive. In this issue of Cancer Discovery, through the development of ligand-specific NOTCH inhibitors, Kangsamaksin and colleagues uncovered unique signaling outcomes downstream of DLL- and JAG-receptor activation and demonstrated their effects in the suppression of tumor angiogenesis. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25656896      PMCID： PMC4342039          DOI： 10.1158/2159-8290.CD-14-1501

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  10 in total

1.  Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.

Authors:  I Rebay; R J Fleming; R G Fehon; L Cherbas; P Cherbas; S Artavanis-Tsakonas
Journal:  Cell       Date:  1991-11-15       Impact factor: 41.582

Review 2.  Notch signaling: simplicity in design, versatility in function.

Authors:  Emma R Andersson; Rickard Sandberg; Urban Lendahl
Journal:  Development       Date:  2011-09       Impact factor: 6.868

Review 3.  Therapeutic modulation of Notch signalling--are we there yet?

Authors:  Emma R Andersson; Urban Lendahl
Journal:  Nat Rev Drug Discov       Date:  2014-05       Impact factor: 84.694

4.  Chronic DLL4 blockade induces vascular neoplasms.

Authors:  Minhong Yan; Christopher A Callahan; Joseph C Beyer; Krishna P Allamneni; Gu Zhang; John Brady Ridgway; Kyle Niessen; Greg D Plowman
Journal:  Nature       Date:  2010-02-11       Impact factor: 49.962

5.  Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

Authors:  Marie Blanke Andrawes; Xiang Xu; Hong Liu; Scott B Ficarro; Jarrod A Marto; Jon C Aster; Stephen C Blacklow
Journal:  J Biol Chem       Date:  2013-07-09       Impact factor: 5.157

6.  NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth.

Authors:  Thaned Kangsamaksin; Aino Murtomaki; Natalie M Kofler; Henar Cuervo; Reyhaan A Chaudhri; Ian W Tattersall; Paul E Rosenstiel; Carrie J Shawber; Jan Kitajewski
Journal:  Cancer Discov       Date:  2014-11-11       Impact factor: 39.397

Review 7.  Notch signalling in solid tumours: a little bit of everything but not all the time.

Authors:  Prathibha Ranganathan; Kelly L Weaver; Anthony J Capobianco
Journal:  Nat Rev Cancer       Date:  2011-04-14       Impact factor: 60.716

8.  The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.

Authors:  Rui Benedito; Cristina Roca; Inga Sörensen; Susanne Adams; Achim Gossler; Marcus Fruttiger; Ralf H Adams
Journal:  Cell       Date:  2009-06-12       Impact factor: 41.582

9.  A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.

Authors:  Shinya Yamamoto; Wu-Lin Charng; Nadia A Rana; Shinako Kakuda; Manish Jaiswal; Vafa Bayat; Bo Xiong; Ke Zhang; Hector Sandoval; Gabriela David; Hao Wang; Robert S Haltiwanger; Hugo J Bellen
Journal:  Science       Date:  2012-11-30       Impact factor: 47.728

Review 10.  The notch ligand JAGGED1 as a target for anti-tumor therapy.

Authors:  Demin Li; Massimo Masiero; Alison H Banham; Adrian L Harris
Journal:  Front Oncol       Date:  2014-09-25       Impact factor: 6.244
  10 in total
  6 in total

Review 1.  The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions.

Authors:  Ivan Lobov; Natalia Mikhailova
Journal:  J Ophthalmol       Date:  2018-07-05       Impact factor: 1.909

2.  A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7).

Authors:  Judy R van Beijnum; Patrycja Nowak-Sliwinska; Maaike van Berkel; Tse J Wong; Arjan W Griffioen
Journal:  Angiogenesis       Date:  2017-09-26       Impact factor: 9.596

3.  Host-Derived Delta-Like Canonical Notch Ligand 1 as a Novel Diagnostic Biomarker for Bacterial Sepsis-Results From a Combinational Secondary Analysis.

Authors:  Dagmar Hildebrand; Sebastian O Decker; Christian Koch; Felix C F Schmitt; Sophie Ruhrmann; Emmanuel Schneck; Michael Sander; Markus Alexander Weigand; Thorsten Brenner; Klaus Heeg; Florian Uhle
Journal:  Front Cell Infect Microbiol       Date:  2019-07-23       Impact factor: 5.293

4.  The role of Notch ligand Jagged1 in osteosarcoma proliferation, metastasis, and recurrence.

Authors:  Jianping Zhang; Na Li; Siyu Lu; Yanling Chen; Lequn Shan; Xingcheng Zhao; Yongqing Xu
Journal:  J Orthop Surg Res       Date:  2021-03-29       Impact factor: 2.359

Review 5.  Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy.

Authors:  Paola M Dantonio; Marianne O Klein; Maria Renata V B Freire; Camila N Araujo; Ana Carolina Chiacetti; Ricardo G Correa
Journal:  Biosci Rep       Date:  2018-10-02       Impact factor: 3.840

6.  Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling.

Authors:  Yen-Ta Chen; Chi-Ruei Huang; Chia-Lo Chang; John Y Chiang; Chi-Wen Luo; Hong-Hwa Chen; Hon-Kan Yip
Journal:  Int J Biol Sci       Date:  2020-07-23       Impact factor: 6.580
  6 in total

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