Literature DB >> 25654138

Roles of DNA Damage Response Proteins in Mitogen-Induced Thp-1 Differentiation into Macrophage.

Eui Young So1, Martin Kozicki1, Toru Ouchi1.   

Abstract

ATM, ATR and DNA-PK are critical for DNA damage response (DDR) and sequential repair, leading to genomic stability. In this study, we found the expression of these proteins is markedly induced by PMA during THP1 differentiation without the change in the level of transcripts. Also, inhibitors of these protein activity suppressed PMA-induced morphological change of THP1 cells. Our results suggest the potential roles of these DDR proteins in cellular differentiation.

Entities:  

Keywords:  Antigen presenting cells; DNA damage response; Severe combined immunodeficiency

Year:  2013        PMID： 25654138      PMCID： PMC4313864     

Source DB:  PubMed          Journal:  J Cancer Biol Res        ISSN： 2373-9436


  13 in total

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Authors:  Tracey A Dobbs; John A Tainer; Susan P Lees-Miller
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5.  DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus.

Authors:  C Jhappan; H C Morse; R D Fleischmann; M M Gottesman; G Merlino
Journal:  Nat Genet       Date:  1997-12       Impact factor: 38.330

6.  The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

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Journal:  Mol Cancer Ther       Date:  2010-01-06       Impact factor: 6.261

7.  Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.

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Journal:  Am J Pathol       Date:  2003-08       Impact factor: 4.307

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Authors:  C Barlow; S Hirotsune; R Paylor; M Liyanage; M Eckhaus; F Collins; Y Shiloh; J N Crawley; T Ried; D Tagle; A Wynshaw-Boris
Journal:  Cell       Date:  1996-07-12       Impact factor: 41.582

9.  Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice.

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3.  Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages.

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