Shitalkumar G Sagari1, Roopa Babannavar2, Abhishek Lohra3, Ashwin Kodgi4, Sunil Bapure5, Yogesh Rao6, Arun J7, Manjunath Malghan8. 1. Senior Lecturer, Department of Oral Pathology & Microbiology, Jodhpur Dental College General Hospital , Jodhpur, Rajasthan, India . 2. Senior Lecturer, Department of Conservative Dentistry & Endodontics, Jodhpur Dental College General Hospital , Jodhpur, Rajasthan, India . 3. Lecturer, Jodhpur School of Public Health, Jodhpur National University , Jodhpur, India . 4. Senior Lecturer, Department of Prosthodontics, MIDSR Dental College and Hospital , Latur, Maharashtra, India . 5. Senior Lecturer, Department of Periodontics, MIDSR Dental College and Hospital , Latur, Maharashtra, India . 6. Senior Lecturer, Department of Prosthodontics, Maharana Pratap Dental College and Research Centre , Gwalior, India . 7. Senior Lecturer, Department of Conservative Dentistry & Endodontics, Bapuji Dental College and Hospital , Davanagere, Karanataka, India . 8. Senior Lecturer, Department of Orthodontics, KLE VK institute of Dental Sciences , Belgaum, Karnataka, India .
Abstract
AIM: Biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers. MATERIALS AND METHODS: Micronucleus frequencies in oral exfoliated cells were done from individuals not known to be exposed to either environmental or occupational carcinogens (Group I). Similarly samples were obtained from full-time Nuclear Power Station (NPS) workers with absence of Leukemia and any malignancy (Group II) and workers diagnosed as leukemic patients and undergoing treatment (Group III). RESULTS: There was statistically significant difference between Group I, Group II & Group III. MN and NA frequencies in Leukemic Patients were significantly higher than those in exposed workers &control groups (p < 0.05). CONCLUSION: MN and other NA reflect genetic changes, events associated with malignancies. Therefore, there is a need to educate those who work in NPS about the potential hazard of occupational exposure and the importance of using protective measures.
AIM: Biomonitoring provides a useful tool to estimate the genetic risk from exposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers. MATERIALS AND METHODS: Micronucleus frequencies in oral exfoliated cells were done from individuals not known to be exposed to either environmental or occupational carcinogens (Group I). Similarly samples were obtained from full-time Nuclear Power Station (NPS) workers with absence of Leukemia and any malignancy (Group II) and workers diagnosed as leukemicpatients and undergoing treatment (Group III). RESULTS: There was statistically significant difference between Group I, Group II & Group III. MN and NA frequencies in LeukemicPatients were significantly higher than those in exposed workers &control groups (p < 0.05). CONCLUSION: MN and other NA reflect genetic changes, events associated with malignancies. Therefore, there is a need to educate those who work in NPS about the potential hazard of occupational exposure and the importance of using protective measures.
Entities:
Keywords:
DNA damage; Exfoliative cytology; Genotoxicity; Micronucleus
Authors: L Popova; D Kishkilova; V B Hadjidekova; R P Hristova; P Atanasova; V V Hadjidekova; D Ziya; V G Hadjidekov Journal: Dentomaxillofac Radiol Date: 2007-03 Impact factor: 2.419
Authors: Ana Maria Oliveira Ferreira da Mata; Marcia Fernanda Correia Jardim Paz; Ag-Anne Pereira Melo de Menezes; Antonielly Campinho Dos Reis; Bruna da Silva Souza; Carlos Dimas de Carvalho Sousa; Sônia Alves Machado; Thiago Soares Gondim Medeiros; Chandan Sarkar; Muhammad Torequl Islam; Javad Sharifi-Rad; Sevgi Durna Daştan; Mohammed M Alshehri; João Marcelo de Castro E Sousa; Ana Amélia de Carvalho Melo Cavalcante Journal: Cancer Cell Int Date: 2022-04-18 Impact factor: 6.429