Literature DB >> 25653428

CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.

Suefen Kwa1, Shanmugalakshmi Sadagopal1, Xiaoying Shen2, Jung Joo Hong3, Sailaja Gangadhara1, Rahul Basu1, Blandine Victor1, Smita S Iyer1, Celia C LaBranche4, David C Montefiori4, Georgia D Tomaras2, Francois Villinger3, Bernard Moss5, Pamela A Kozlowski6, Rama Rao Amara7.   

Abstract

Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25653428      PMCID： PMC4442387          DOI： 10.1128/JVI.03527-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  8 in total

1.  Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

Authors:  R R Amara; F Villinger; J D Altman; S L Lydy; S P O'Neil; S I Staprans; D C Montefiori; Y Xu; J G Herndon; L S Wyatt; M A Candido; N L Kozyr; P L Earl; J M Smith; H L Ma; B D Grimm; M L Hulsey; J Miller; H M McClure; J M McNicholl; B Moss; H L Robinson
Journal:  Science       Date:  2001-04-06       Impact factor: 47.728

2.  Preexisting vaccinia virus immunity decreases SIV-specific cellular immunity but does not diminish humoral immunity and efficacy of a DNA/MVA vaccine.

Authors:  Sunil Kannanganat; Pragati Nigam; Vijayakumar Velu; Patricia L Earl; Lilin Lai; Lakshmi Chennareddi; Benton Lawson; Robert L Wilson; David C Montefiori; Pamela A Kozlowski; Bernard Moss; Harriet L Robinson; Rama Rao Amara
Journal:  J Immunol       Date:  2010-11-12       Impact factor: 5.422

3.  Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape.

Authors:  Jung Joo Hong; Praveen K Amancha; Kenneth Rogers; Aftab A Ansari; Francois Villinger
Journal:  J Immunol       Date:  2012-03-02       Impact factor: 5.422

4.  Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251.

Authors:  Koen K A Van Rompay; Jennifer L Greenier; Kelly Stefano Cole; Patricia Earl; Bernard Moss; Jonathan D Steckbeck; Bapi Pahar; Tracy Rourke; Ronald C Montelaro; Don R Canfield; Ross P Tarara; Christopher Miller; Michael B McChesney; Marta L Marthas
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

5.  CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus SIV239 vaccine enhances SIV-specific humoral and cellular immunity and improves protection against a heterologous SIVE660 mucosal challenge.

Authors:  Suefen Kwa; Lilin Lai; Sailaja Gangadhara; Mariam Siddiqui; Vinod B Pillai; Celia Labranche; Tianwei Yu; Bernard Moss; David C Montefiori; Harriet L Robinson; Pamela A Kozlowski; Rama Rao Amara
Journal:  J Virol       Date:  2014-06-11       Impact factor: 5.103

6.  Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals.

Authors:  Georgia D Tomaras; James M Binley; Elin S Gray; Emma T Crooks; Keiko Osawa; Penny L Moore; Nancy Tumba; Tommy Tong; Xiaoying Shen; Nicole L Yates; Julie Decker; Constantinos Kurt Wibmer; Feng Gao; S Munir Alam; Philippa Easterbrook; Salim Abdool Karim; Gift Kamanga; John A Crump; Myron Cohen; George M Shaw; John R Mascola; Barton F Haynes; David C Montefiori; Lynn Morris
Journal:  J Virol       Date:  2011-08-17       Impact factor: 5.103

7.  Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa.

Authors:  Geetha H Mylvaganam; Vijayakumar Velu; Jung-Joo Hong; Shanmugalakshmi Sadagopal; Suefen Kwa; Rahul Basu; Benton Lawson; Francois Villinger; Rama Rao Amara
Journal:  J Immunol       Date:  2014-09-22       Impact factor: 5.422

8.  Heterogeneity in neutralization sensitivities of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock.

Authors:  Michael Lopker; Juliet Easlick; Sarah Sterrett; Julie M Decker; Hannah Barbian; Gerald Learn; Brandon F Keele; James E Robinson; Hui Li; Beatrice H Hahn; George M Shaw; Katharine J Bar
Journal:  J Virol       Date:  2013-03-06       Impact factor: 5.103
  8 in total
  23 in total

1.  Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.

Authors:  Geetha H Mylvaganam; Daniel Rios; Hadia M Abdelaal; Smita Iyer; Gregory Tharp; Maud Mavigner; Sakeenah Hicks; Ann Chahroudi; Rafi Ahmed; Steven E Bosinger; Ifor R Williams; Pamela J Skinner; Vijayakumar Velu; Rama R Amara
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-03       Impact factor: 11.205

2.  Oral Immunization with a Recombinant Lactococcus lactis-Expressing HIV-1 Antigen on Group A Streptococcus Pilus Induces Strong Mucosal Immunity in the Gut.

Authors:  Venkateswarlu Chamcha; Andrew Jones; Bernard R Quigley; June R Scott; Rama Rao Amara
Journal:  J Immunol       Date:  2015-10-19       Impact factor: 5.422

3.  Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells.

Authors:  Vijayakumar Velu; Geetha Hanna Mylvaganam; Sailaja Gangadhara; Jung Joo Hong; Smita S Iyer; Sanjeev Gumber; Chris C Ibegbu; Francois Villinger; Rama Rao Amara
Journal:  J Immunol       Date:  2016-08-01       Impact factor: 5.422

4.  Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques.

Authors:  Sabrina Helmold Hait; Diego A Vargas-Inchaustegui; Thomas Musich; Venkatramanan Mohanram; Iskra Tuero; David J Venzon; Jenifer Bear; Margherita Rosati; Monica Vaccari; Genoveffa Franchini; Barbara K Felber; George N Pavlakis; Marjorie Robert-Guroff
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

Review 5.  Immunogenicity and efficacy of DNA/MVA HIV vaccines in rhesus macaque models.

Authors:  Lynette Siv Chea; Rama Rao Amara
Journal:  Expert Rev Vaccines       Date:  2017-09-04       Impact factor: 5.217

6.  Human Immunodeficiency Virus C.1086 Envelope gp140 Protein Boosts following DNA/Modified Vaccinia Virus Ankara Vaccination Fail To Enhance Heterologous Anti-V1V2 Antibody Response and Protection against Clade C Simian-Human Immunodeficiency Virus Challenge.

Authors:  Tiffany M Styles; Sailaja Gangadhara; Pradeep B J Reddy; Sakeenah Hicks; Celia C LaBranche; David C Montefiori; Cynthia A Derdeyn; Pamela A Kozlowski; Vijayakumar Velu; Rama Rao Amara
Journal:  J Virol       Date:  2019-09-30       Impact factor: 5.103

7.  HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.

Authors:  Wilton B Williams; Hua-Xin Liao; M Anthony Moody; Thomas B Kepler; S Munir Alam; Feng Gao; Kevin Wiehe; Ashley M Trama; Kathryn Jones; Ruijun Zhang; Hongshuo Song; Dawn J Marshall; John F Whitesides; Kaitlin Sawatzki; Axin Hua; Pinghuang Liu; Matthew Z Tay; Kelly E Seaton; Xiaoying Shen; Andrew Foulger; Krissey E Lloyd; Robert Parks; Justin Pollara; Guido Ferrari; Jae-Sung Yu; Nathan Vandergrift; David C Montefiori; Magdalena E Sobieszczyk; Scott Hammer; Shelly Karuna; Peter Gilbert; Doug Grove; Nicole Grunenberg; M Juliana McElrath; John R Mascola; Richard A Koup; Lawrence Corey; Gary J Nabel; Cecilia Morgan; Gavin Churchyard; Janine Maenza; Michael Keefer; Barney S Graham; Lindsey R Baden; Georgia D Tomaras; Barton F Haynes
Journal:  Science       Date:  2015-07-30       Impact factor: 47.728

8.  Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.

Authors:  Venkateswarlu Chamcha; Pradeep B J Reddy; Sunil Kannanganat; Courtney Wilkins; Sailaja Gangadhara; Vijayakumar Velu; Richard Green; G Lynn Law; Jean Chang; James R Bowen; Pamela A Kozlowski; Michelle Lifton; Sampa Santra; Traci Legere; Lynette S Chea; Lakshmi Chennareddi; Tianwei Yu; Mehul S Suthar; Guido Silvestri; Cynthia A Derdeyn; Michael Gale; Francois Villinger; Eric Hunter; Rama Rao Amara
Journal:  Sci Transl Med       Date:  2019-11-20       Impact factor: 17.956

9.  Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques.

Authors:  Kara Jensen; Rafiq Nabi; Koen K A Van Rompay; Spencer Robichaux; Jeffrey D Lifson; Michael Piatak; William R Jacobs; Glenn Fennelly; Don Canfield; Katie R Mollan; Michael G Hudgens; Michelle H Larsen; Angela M Amedee; Pamela A Kozlowski; Kristina De Paris
Journal:  J Virol       Date:  2016-07-27       Impact factor: 5.103

10.  Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques.

Authors:  Isabela Silva de Castro; Shari N Gordon; Jun Liu; Massimiliano Bissa; Katherine McKinnon; Hung V Trinh; Melvin N Doster; Luca Schifanella; Namal P Liyanage; JinChao Cao; Olivia Cheng; Kathryn Foulds; Mario Roederer; Richard A Koup; Xiaoying Shen; Georgia D Tomaras; David J Venzon; Donald N Forthal; Timothy Fouts; David C Montefiori; Jim Tartaglia; Mangala Rao; Mario Ostrowski; Genoveffa Franchini; Monica Vaccari
Journal:  J Virol       Date:  2020-02-28       Impact factor: 5.103
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