| Literature DB >> 11393868 |
R R Amara1, F Villinger, J D Altman, S L Lydy, S P O'Neil, S I Staprans, D C Montefiori, Y Xu, J G Herndon, L S Wyatt, M A Candido, N L Kozyr, P L Earl, J M Smith, H L Ma, B D Grimm, M L Hulsey, J Miller, H M McClure, J M McNicholl, B Moss, H L Robinson.
Abstract
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.Entities:
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Year: 2001 PMID： 11393868 DOI： 10.1126/science.1058915
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728