| Literature DB >> 25651172 |
Elizabeth M McNally1, David Y Barefield2, Megan J Puckelwartz2.
Abstract
Heart failure is highly influenced by heritability, and nearly 100 genes link to familial cardiomyopathy. Despite the marked genetic diversity that underlies these complex cardiovascular phenotypes, several key genes and pathways have emerged. Hypertrophic cardiomyopathy is characterized by increased contractility and a greater energetic cost of cardiac output. Dilated cardiomyopathy is often triggered by mutations that disrupt the giant protein titin. The energetic consequences of these mutations offer molecular targets and opportunities for new drug development and gene correction therapies.Entities:
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Year: 2015 PMID： 25651172 PMCID： PMC4331062 DOI： 10.1016/j.cmet.2015.01.013
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287