Literature DB >> 25641804

Overcoming multiple drug resistance by spatial-temporal synchronization of epirubicin and pooled siRNAs.

Wei Chen1, Xueyao Liu, Yun Xiao, Ruikang Tang.   

Abstract

One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP). The resulting EPI-RNA-CaP nanocomplexes can achieve a spatial-temporal synchronous effect to full-scale overcome sophisticated multiple drug resistance (MDR) by simultaneous inhibitions of drug efflux and intracellular anti-apoptotic defense to maximize the therapeutic efficacy.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RNA interference; epirubicin; gene therapy; multiple drug resistance; synergistic effect

Mesh：

Substances：

Year:  2015        PMID： 25641804     DOI： 10.1002/smll.201402377

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  5 in total

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Journal:  Curr Med Sci       Date:  2018-12-07

Review 2.  Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery.

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Journal:  Nat Commun       Date:  2017-11-24       Impact factor: 14.919

Review 4.  Role of Nanotechnology in Overcoming the Multidrug Resistance in Cancer Therapy: A Review.

Authors:  Suhail Ahmad Mir; Laraibah Hamid; Ghulam Nabi Bader; Ambreen Shoaib; Mohamed Rahamathulla; Mohammad Y Alshahrani; Prawez Alam; Faiyaz Shakeel
Journal:  Molecules       Date:  2022-10-05       Impact factor: 4.927

5.  Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance.

Authors:  Yinghuan Li; Xi Tan; Xuhan Liu; Lingyan Liu; Yan Fang; Rong Rao; Yuanyuan Ren; Xiangliang Yang; Wei Liu
Journal:  Asian J Pharm Sci       Date:  2019-11-12       Impact factor: 6.598
  5 in total

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