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Literature DB >> 25641765

Circadian clock genes: effects on dopamine, reward and addiction.

Puja K Parekh¹, Angela R Ozburn², Colleen A McClung³.

Abstract

Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.

Entities: Chemical Disease Gene Species

Keywords: Addiction; Alcohol; Circadian; Dopamine

Mesh：

Substances：

Year: 2015 PMID： 25641765 PMCID： PMC4457686 DOI： 10.1016/j.alcohol.2014.09.034

Source DB: PubMed Journal: Alcohol ISSN： 0741-8329 Impact factor: 2.405

111 in total

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49 in total

1. Differential Effects of Addictive Drugs on Sleep and Sleep Stages.

Authors: Harold W Gordon
Journal: J Addict Res (OPAST Group) Date: 2019-07-15

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Journal: Neuromolecular Med Date: 2018-03-23 Impact factor: 3.843