Literature DB >> 25640897

Ligand-directed profiling of organelles with internalizing phage libraries.

Andrey S Dobroff1,2,3, Roberto Rangel4,3, Liliana Guzman-Roja4,3, Carolina C Salmeron1,2, Juri G Gelovani5, Richard L Sidman6, Cristian G Bologa7, Tudor I Oprea7, C Jeffrey Brinker8, Renata Pasqualini2,9, Wadih Arap1,9.   

Abstract

Phage display is a resourceful tool to, in an unbiased manner, discover and characterize functional protein-protein interactions, create vaccines, and engineer peptides, antibodies, and other proteins as targeted diagnostic and/or therapeutic agents. Recently, our group has developed a new class of internalizing phage (iPhage) for ligand-directed targeting of organelles and to identify molecular pathways within live cells. This unique technology is suitable for applications ranging from fundamental cell biology to drug development. This unit describes the methods for generating and screening the iPhage display system, and explains how to select and validate candidate internalizing homing peptide.
Copyright © 2015 John Wiley & Sons, Inc.

Entities:  

Keywords:  intracellular receptors; intracellular targeting; mammalian cells; organelles; penetratin; peptides; phage display; proteomics

Mesh：

Year:  2015        PMID： 25640897      PMCID： PMC4339060          DOI： 10.1002/0471140864.ps3004s79

Source DB:  PubMed          Journal:  Curr Protoc Protein Sci        ISSN： 1934-3655


  42 in total

1.  Quantitative PCR-based approach for rapid phage display analysis: a foundation for high throughput vascular proteomic profiling.

Authors:  Victoria L T Ballard; Jacquelyne M Holm; Jay M Edelberg
Journal:  Physiol Genomics       Date:  2006-05-16       Impact factor: 3.107

Review 2.  Phage display derived therapeutic antibodies.

Authors:  Holger Thie; Torsten Meyer; Thomas Schirrmann; Michael Hust; Stefan Dübel
Journal:  Curr Pharm Biotechnol       Date:  2008-12       Impact factor: 2.837

3.  Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis.

Authors:  Emmanuel Dias-Neto; Diana N Nunes; Ricardo J Giordano; Jessica Sun; Gregory H Botz; Kuan Yang; João C Setubal; Renata Pasqualini; Wadih Arap
Journal:  PLoS One       Date:  2009-12-17       Impact factor: 3.240

4.  Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients.

Authors:  Fernanda I Staquicini; Marina Cardó-Vila; Mikhail G Kolonin; Martin Trepel; Julianna K Edwards; Diana N Nunes; Anna Sergeeva; Eleni Efstathiou; Jessica Sun; Nalvo F Almeida; Shi-Ming Tu; Gregory H Botz; Michael J Wallace; David J O'Connell; Stan Krajewski; Jeffrey E Gershenwald; Jeffrey J Molldrem; Anne L Flamm; Erkki Koivunen; Rebecca D Pentz; Emmanuel Dias-Neto; João C Setubal; Dolores J Cahill; Patricia Troncoso; Kim-Ahn Do; Christopher J Logothetis; Richard L Sidman; Renata Pasqualini; Wadih Arap
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-02       Impact factor: 11.205

Review 5.  Nanoparticle therapeutics: an emerging treatment modality for cancer.

Authors:  Mark E Davis; Zhuo Georgia Chen; Dong M Shin
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694

6.  An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.

Authors:  Paul J Mintz; Marina Cardó-Vila; Michael G Ozawa; Amin Hajitou; Roberto Rangel; Liliana Guzman-Rojas; Dawn R Christianson; Marco A Arap; Ricardo J Giordano; Glauco R Souza; Jeffrey Easley; Ahmad Salameh; Salvatore Oliviero; Ricardo R Brentani; Erkki Koivunen; Wadih Arap; Renata Pasqualini
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-23       Impact factor: 11.205

7.  The CARLSBAD database: a confederated database of chemical bioactivities.

Authors:  Stephen L Mathias; Jarrett Hines-Kay; Jeremy J Yang; Gergely Zahoransky-Kohalmi; Cristian G Bologa; Oleg Ursu; Tudor I Oprea
Journal:  Database (Oxford)       Date:  2013-06-21       Impact factor: 3.451

Review 8.  Peptide phage display as a tool for drug discovery: targeting membrane receptors.

Authors:  Peter Molek; Borut Strukelj; Tomaz Bratkovic
Journal:  Molecules       Date:  2011-01-21       Impact factor: 4.411

9.  Enhancing navigation in biomedical databases by community voting and database-driven text classification.

Authors:  Timo Duchrow; Timur Shtatland; Daniel Guettler; Misha Pivovarov; Stefan Kramer; Ralph Weissleder
Journal:  BMC Bioinformatics       Date:  2009-10-03       Impact factor: 3.169

10.  A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.

Authors:  Marina Cardó-Vila; Amado J Zurita; Ricardo J Giordano; Jessica Sun; Roberto Rangel; Liliana Guzman-Rojas; Cristiane D Anobom; Ana P Valente; Fábio C L Almeida; Johanna Lahdenranta; Mikhail G Kolonin; Wadih Arap; Renata Pasqualini
Journal:  PLoS One       Date:  2008-10-20       Impact factor: 3.240
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  1 in total

1.  Phage display peptide libraries: deviations from randomness and correctives.

Authors:  Arie Ryvkin; Haim Ashkenazy; Yael Weiss-Ottolenghi; Chen Piller; Tal Pupko; Jonathan M Gershoni
Journal:  Nucleic Acids Res       Date:  2018-05-18       Impact factor: 16.971
  1 in total

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