Literature DB >> 25636870

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn.

Sri Fatmawati1, Taslim Ersam2, Kuniyoshi Shimizu3.   

Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 µg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 µM.
Copyright © 2014 Elsevier GmbH. All rights reserved.

Entities:  

Keywords:  Aldose reductase; Diabetic complications; Garcinia mangostana; Mangostin; Xanthone

Mesh：

Substances：

Year:  2014        PMID： 25636870     DOI： 10.1016/j.phymed.2014.11.001

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  6 in total

1.  Thymol, a monoterpene, inhibits aldose reductase and high-glucose-induced cataract on isolated goat lens.

Authors:  Divya M Kanchan; Smita S Kale; Gauresh S Somani; Aakruti A Kaikini; Sadhana Sathaye
Journal:  J Pharm Bioallied Sci       Date:  2016 Oct-Dec

2.  Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies.

Authors:  Faisal Usman; Hamid Saeed Shah; Sumera Zaib; Sirikhwan Manee; Jahanzeb Mudassir; Ajmal Khan; Gaber El-Saber Batiha; Khamael M Abualnaja; Dalal Alhashmialameer; Imtiaz Khan
Journal:  Molecules       Date:  2021-11-01       Impact factor: 4.411

3.  Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (Garcinia mangostana).

Authors:  Xiaofang Li; Haoze Chen; Yan Jia; Jinming Peng; Chunmei Li
Journal:  Foods       Date:  2022-03-29

4.  Effects of α-Mangostin on Viability, Growth and Cohesion of Multicellular Spheroids Derived from Human Breast Cancer Cell Lines.

Authors:  Giuseppe Scolamiero; Claudia Pazzini; Francesca Bonafè; Carlo Guarnieri; Claudio Muscari
Journal:  Int J Med Sci       Date:  2018-01-01       Impact factor: 3.738

5.  Synergistic interaction of a consortium of the brown-rot fungus Fomitopsis pinicola and the bacterium Ralstonia pickettii for DDT biodegradation.

Authors:  Adi Setyo Purnomo; Atmira Sariwati; Ichiro Kamei
Journal:  Heliyon       Date:  2020-06-07

Review 6.  Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research.

Authors:  Vuanghao Lim; Edward Schneider; Hongli Wu; Iok-Hou Pang
Journal:  Nutrients       Date:  2018-10-26       Impact factor: 5.717
  6 in total

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