C M R Ouédraogo1, R M L Rahimy2, T M Zohoncon3, F W Djigma3, A T Yonli3, D Ouermi3, A Sanni4, J Lankoande5, J Simpore3. 1. Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Gynécologues obstétriciens, CHU Yalgado Ouédraogo de Ouagadougou, 04 BP 8201, Ouagadougou 04, Burkina Faso. Electronic address: ocharlemagne@yahoo.fr. 2. Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso. 3. Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Centre de recherche biomoléculaire « Pietro Annigoni » Cerba/Labiogène, centre médical Saint-Camille, Ouagadougou, Burkina Faso. 4. Université d'Abomey-Calavi, Bénin. 5. Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso; Gynécologues obstétriciens, CHU Yalgado Ouédraogo de Ouagadougou, 04 BP 8201, Ouagadougou 04, Burkina Faso.
Abstract
OBJECTIVE: This cross-sectional study was to determine the prevalence and characterization of high-risk HPV genotypes circulating among adolescents in Ouagadougou. METHODS: From September to December 2013, 200 adolescents recruited from a youth counseling center have voluntarily accepted a swab of the endocervical canal. The identification of the genotypes of the human Papillomavirus (HPV) was performed by real-time polymerase chain reaction technique. RESULTS: The mean age of adolescents was 18.7±0.7 years and 83/200 adolescents were positive for at least one high-risk genotype HPV a prevalence of 41.5%. Twelve genotypes corresponding to 136 infections were characterized: HPV 52 (22.8%), HPV 59 (14.0%), HPV 39 (13.2%), HPV 35 (10.3%), HPV 51 (10.3%), HPV 56 (8.8%), HPV 16 (5.2%), HPV 18 (5.2%), HPV 58 (4.4%), HPV 31 (3.6%), HPV 45 (1.5%), HPV 33 (0.7%). Multiple infections (2-5 virus) statistically associated with age (p=0.0318) was detected in 42.2% of infected females. If the number of sexual partners was statistically associated with the porting of HPV (OR=2.18; 95% CI=1.17 to 4.09), early sexual intercourse and the recent change of sexual partner were not (p>0,05) CONCLUSION: The prevalence of carriage of HPV in this study is high, as described in young people at the start of sexual activity. Identified genotypes are different from those targeted by prophylactic vaccines currently available. A larger study to map genotypes of high-risk HPV circulating in West Africa is necessary for a suitable vaccine.
OBJECTIVE: This cross-sectional study was to determine the prevalence and characterization of high-risk HPV genotypes circulating among adolescents in Ouagadougou. METHODS: From September to December 2013, 200 adolescents recruited from a youth counseling center have voluntarily accepted a swab of the endocervical canal. The identification of the genotypes of the human Papillomavirus (HPV) was performed by real-time polymerase chain reaction technique. RESULTS: The mean age of adolescents was 18.7±0.7 years and 83/200 adolescents were positive for at least one high-risk genotype HPV a prevalence of 41.5%. Twelve genotypes corresponding to 136 infections were characterized: HPV 52 (22.8%), HPV 59 (14.0%), HPV 39 (13.2%), HPV 35 (10.3%), HPV 51 (10.3%), HPV 56 (8.8%), HPV 16 (5.2%), HPV 18 (5.2%), HPV 58 (4.4%), HPV 31 (3.6%), HPV 45 (1.5%), HPV 33 (0.7%). Multiple infections (2-5 virus) statistically associated with age (p=0.0318) was detected in 42.2% of infected females. If the number of sexual partners was statistically associated with the porting of HPV (OR=2.18; 95% CI=1.17 to 4.09), early sexual intercourse and the recent change of sexual partner were not (p>0,05) CONCLUSION: The prevalence of carriage of HPV in this study is high, as described in young people at the start of sexual activity. Identified genotypes are different from those targeted by prophylactic vaccines currently available. A larger study to map genotypes of high-risk HPV circulating in West Africa is necessary for a suitable vaccine.
Authors: Akouélé P Kuassi-Kpede; Essolakina Dolou; Théodora M Zohoncon; Ina Marie Angèle Traore; Gnatoulma Katawa; R Alice Ouedraogo; Esther Mah Traore; Prosper Bado; T Clarisse Ouedraogo; Florencia Wendkuuni Djigma; Simplice Damintoti Karou; Jacques Simpore Journal: BMC Infect Dis Date: 2021-03-19 Impact factor: 3.090
Authors: Essolakina Dolou; Akouélé Kuassi-Kpede; Theodora M Zohoncon; Ina Marie Traore; Gnatoulma Katawa; Alice R Ouedraogo; Esther Mah Traore; Prosper Bado; Clarisse T Ouedraogo; Florencia Djigma; Abdoul-Samadou Aboubakari; Simplice Damintoti Karou; Jacques Simpore Journal: Afr Health Sci Date: 2021-12 Impact factor: 0.927
Authors: Ina Marie Angèle Traore; Théodora Mahoukèdè Zohoncon; Adama Dembele; Florencia W Djigma; Dorcas Obiri-Yeboah; Germain Traore; Moussa Bambara; Charlemagne Ouedraogo; Yves Traore; Jacques Simpore Journal: Biomed Res Int Date: 2016-07-20 Impact factor: 3.411