| Literature DB >> 25636677 |
Maureen S Durkin1, Lindsay A DuBois, Matthew J Maenner.
Abstract
Recent studies have reported an increased risk of autism among second-born children conceived <12 versus >36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum disorder (ASD) risk in a Wisconsin birth cohort of 31,467 second-born children, of whom 160 resided in the study area and were found to have ASD at age 8 years. In adjusted analyses, both short (<12) and long (>84 month) IPIs were associated with a two-fold risk of ASD relative to IPIs of 24-47 months (p < 0.05). The long IPI association was partially confounded by history of previous pregnancy loss.Entities:
Mesh：
Year: 2015 PMID： 25636677 PMCID： PMC4474747 DOI： 10.1007/s10803-015-2368-y
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257