B P Zhu1, R T Rolfs, B E Nangle, J M Horan. 1. Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, USA. zhub@state.mi.us
Abstract
BACKGROUND: A short interval between pregnancies has been associated with adverse perinatal outcomes. Whether that association is due to confounding by other risk factors, such as maternal age, socioeconomic status, and reproductive history, is unknown. METHODS: We evaluated the interpregnancy interval in relation to low birth weight, preterm birth, and small size for gestational age by analyzing data from the birth certificates of 173,205 singleton infants born alive to multiparous mothers in Utah from 1989 to 1996. RESULTS: Infants conceived 18 to 23 months after a previous live birth had the lowest risks of adverse perinatal outcomes; shorter and longer interpregnancy intervals were associated with higher risks. These associations persisted when the data were stratified according to and controlled for 16 biologic, sociodemographic, and behavioral risk factors. As compared with infants conceived 18 to 23 months after a live birth, infants conceived less than 6 months after a live birth had odds ratios of 1.4 (95 percent confidence interval, 1.3 to 1.6) for low birth weight, 1.4 (95 percent confidence interval, 1.3 to 1.5) for preterm birth, and 1.3 (95 percent confidence interval, 1.2 to 1.4) for small size for gestational age; infants conceived 120 months or more after a live birth had odds ratios of 2.0 (95 percent confidence interval, 1.7 to 2.4);1.5 (95 percent confidence interval, 1.3 to 1.7), and 1.8 (95 percent confidence interval, 1.6 to 2.0) for these three adverse outcomes, respectively, when we controlled for all 16 risk factors with logistic regression. CONCLUSIONS: The optimal interpregnancy interval for preventing adverse perinatal outcomes is 18 to 23 months.
BACKGROUND: A short interval between pregnancies has been associated with adverse perinatal outcomes. Whether that association is due to confounding by other risk factors, such as maternal age, socioeconomic status, and reproductive history, is unknown. METHODS: We evaluated the interpregnancy interval in relation to low birth weight, preterm birth, and small size for gestational age by analyzing data from the birth certificates of 173,205 singleton infants born alive to multiparous mothers in Utah from 1989 to 1996. RESULTS:Infants conceived 18 to 23 months after a previous live birth had the lowest risks of adverse perinatal outcomes; shorter and longer interpregnancy intervals were associated with higher risks. These associations persisted when the data were stratified according to and controlled for 16 biologic, sociodemographic, and behavioral risk factors. As compared with infants conceived 18 to 23 months after a live birth, infants conceived less than 6 months after a live birth had odds ratios of 1.4 (95 percent confidence interval, 1.3 to 1.6) for low birth weight, 1.4 (95 percent confidence interval, 1.3 to 1.5) for preterm birth, and 1.3 (95 percent confidence interval, 1.2 to 1.4) for small size for gestational age; infants conceived 120 months or more after a live birth had odds ratios of 2.0 (95 percent confidence interval, 1.7 to 2.4);1.5 (95 percent confidence interval, 1.3 to 1.7), and 1.8 (95 percent confidence interval, 1.6 to 2.0) for these three adverse outcomes, respectively, when we controlled for all 16 risk factors with logistic regression. CONCLUSIONS: The optimal interpregnancy interval for preventing adverse perinatal outcomes is 18 to 23 months.
Entities:
Keywords:
Americas; Biology; Birth Intervals; Birth Spacing; Birth Weight; Body Weight; Child Health; Demographic Factors; Developed Countries; Examinations And Diagnoses; Family Planning; Fertility; Fertility Measurements; Fetus; Gestational Age; Health; Low Birth Weight; North America; Northern America; Physiology; Population; Population Dynamics; Pregnancy; Pregnancy Outcomes; Premature Birth; Reproduction; Size; United States; Utah
Authors: Stefanie N Hinkle; Paul S Albert; Pauline Mendola; Lindsey A Sjaarda; Edwina Yeung; Nansi S Boghossian; S Katherine Laughon Journal: Paediatr Perinat Epidemiol Date: 2013-12-09 Impact factor: 3.980
Authors: Rose G Radin; Lindsey A Sjaarda; Neil J Perkins; Robert M Silver; Zhen Chen; Laurie L Lesher; Noya Galai; Jean Wactawski-Wende; Sunni L Mumford; Enrique F Schisterman Journal: J Clin Endocrinol Metab Date: 2017-01-01 Impact factor: 5.958